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TADA2A Antibody

  • 货号：
    CSB-PA004223
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COLO205 cells using TADA2L Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O75478
  • 基因名：
    TADA2A
  • 别名：
    TADA2A antibody; TADA2L antibody; KL04P antibody; Transcriptional adapter 2-alpha antibody; Transcriptional adapter 2-like antibody; ADA2-like protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat,Monkey
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human TADA2L.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.
  • 基因功能参考文献：
    1. results thus demonstrate that the catalytic activity of GCN5 is stimulated by subunits of the ADA2a- or ADA2b-containing HAT modules and is further increased by incorporation of the distinct HAT modules in the ATAC or SAGA holo-complexes PMID: 26468280
    2. Single nucleotide polymorphism in ADA2 gene is associated with type 1 diabetes. PMID: 25492086
    3. CCDC134 increased the PCAF-dependent K320 acetylation of p53 and p53 protein stability in the presence of hADA2a overexpression. PMID: 22644376
    4. The three-dimensional solution structure of the SWIRM domain from the human transcriptional adaptor ADA2alpha was reported. PMID: 16299514
    5. hADA2a and hADA3 as crucial cofactors of beta-catenin that are likely involved in the assembly of transactivation-competent beta-catenin complexes at Wnt target genes. PMID: 18059173

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  • 亚细胞定位：
    Nucleus. Chromosome.
  • 组织特异性：
    Expressed in all tissues, but most abundantly in testis.
  • 数据库链接：

    HGNC: 11531

    OMIM: 602276

    KEGG: hsa:6871

    STRING: 9606.ENSP00000225396

    UniGene: Hs.500066