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TACC1 Antibody

  • 货号：
    CSB-PA050197
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    O75410
  • 基因名：
    TACC1
  • 别名：
    DKFZp686K18126 antibody; Ga 55 antibody; Ga55 antibody; Gastric cancer antigen Ga 55 antibody; Gastric cancer antigen Ga55 antibody; KIAA1103 antibody; TACC 1 antibody; Tacc1 antibody; TACC1_HUMAN antibody; Taxin 1 antibody; Taxin-1 antibody; Taxin1 antibody; Transforming acidic coiled coil containing protein 1 antibody; Transforming acidic coiled-coil-containing protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human TACC1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways. Might promote the nuclear localization of the receptors. Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.
  • 基因功能参考文献：
    1. The correlation between TACC1 expression and HER-2-positive status indicates synergistic regulation of these two prognostic markers in gastric carcinoma patients. PMID: 25297519
    2. TFF3 and TACC1 over-expression in epithelial cells of surgically resected gastric cancer tissues was an independent predictor of short survival in gastric cancer patients. PMID: 24358147
    3. These findings provide proof and the foundation for the molecular and biological relationships of ErbB-2 and TACC1 in breast cancer. PMID: 23354013
    4. study reports that a small subset of glioblastoma multiforme tumors harbors oncogenic chromosomal translocations that fuse in-frame the tyrosine kinase coding domains of fibroblast growth factor receptor genes(FGFR1 or FGFR3) to the transforming acidic coiled-coil coding domains of TACC1 or TACC3; the FGFR-TACC fusion protein displays oncogenic activity PMID: 22837387
    5. TACC1 depletion in the cell led to decreased RARalpha and TRalpha ligand-dependent transcriptional activity and to delocalization of TR from the nucleus to the cytoplasm. PMID: 20078863
    6. Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells PMID: 11903063
    7. Down regulation of tacc1 controls mrna homeostasis in polarized cells and participates in oncogenic processes in human cancers PMID: 12165861
    8. REVIEW: genetics, expression, gene expression regulation, and function studies PMID: 12389629
    9. Splicing pattern of its mRNA is altered in stomach cancer PMID: 12547166
    10. TACC1 and the mitotic kinase Aurora B belong to the same complex during cytokinesis. PMID: 15064709
    11. Splice variants can be localized to different subcellular compartments in a cell-and tissue-specific manner. PMID: 16496324
    12. TACC1 and a three-gene expression signature (TACC1, NOV, and PTTG1) were identified as independent prognostic markers. PMID: 18984771

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody.; [Isoform 5]: Membrane; Lipid-anchor.; [Isoform 10]: Cytoplasm.
  • 蛋白家族：
    TACC family
  • 组织特异性：
    Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gast
  • 数据库链接：

    HGNC: 11522

    OMIM: 605301

    KEGG: hsa:6867

    STRING: 9606.ENSP00000321703

    UniGene: Hs.279245