Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. TAB3 Antibody

TAB3 Antibody

  • 货号：
    CSB-PA850806LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry analysis of human skeletal muscle tissue using CSB-PA850806LA01HU at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA850806LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TAB3 Polyclonal antibody
  • Uniprot No.：
    Q8N5C8
  • 基因名：
  • 别名：
    MAP3K7IP 3 antibody; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 antibody; NAP1 antibody; NF-kappa-B-activating protein 1 antibody; NFkB activating protein 1 antibody; TAB-3 antibody; Tab3 antibody; TAB3_HUMAN antibody; TAK1 binding protein 3 antibody; TAK1-binding protein 3 antibody; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 antibody; TGF-beta-activated kinase 1-binding protein 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 protein (361-712AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TAB3 Antibody (CSB-PA850806LA01HU)，的标记方式是Non-conjugated。对于TAB3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA850806LB01HU TAB3 Antibody, HRP conjugated ELISA
    FITC CSB-PA850806LC01HU TAB3 Antibody, FITC conjugated
    Biotin CSB-PA850806LD01HU TAB3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1.; May be an oncogenic factor.
  • 基因功能参考文献：
    1. these results demonstrated that TAB3 may be a promising therapeutic target for the treatment of Esophageal squamous cell carcinoma. PMID: 30226617
    2. The combination of WES, genomic triangulation, and systems biology has uncovered perturbations in TGF-beta activated kinase 1 signaling as a novel pathogenic substrate for polyvalvular syndrome. PMID: 27452334
    3. Our study provides insights into the mechanism of TAB3 regulating activity and suggests its important implications in triple negative breast cancer metastasis. PMID: 27009840
    4. Data show that knockdown of transforming growth factor-activated kinase 1 (TAK1)-binding protein 3 (TAB3) inhibited proliferation of non-small cell lung cancer (NSCLC) cells. PMID: 26476534
    5. TAB3 regulated ovarian cancer cell bioactivity and chemotherapy performance via the NF-kappaB pathway. PMID: 27651027
    6. Upregulation of miR-532-5p and subsequent suppression of the SESTD1 and TAB3 genes represent an antiviral response aimed at limiting West Nile virus infection. PMID: 26676784
    7. miR-30a in MSCs may participate in the immune dysregulation of the maternal-fetal interface during PE PMID: 26555189
    8. miR-26b suppresses NF-kappaB signaling and sensitizes hepatocellular carcinoma cells to doxorubicin-induced apoptosis by inhibiting the expression of TAK1 and TAB3. PMID: 24565101
    9. conclude that TRIM38 negatively regulates TNFalpha- and IL-1beta-induced signaling by mediating lysosome-dependent degradation of TAB2/3, two critical components in TNFalpha- and IL-1beta-induced signaling pathways PMID: 24434549
    10. Studies show that three proteins expressed in HEK-293T cells (NAP1, TANK and TBKBP1) interact with TBK1. PMID: 23286385
    11. MiR-23b suppresses IL-17-, tumor necrosis factor alpha (TNF-alpha)- or IL-1beta-induced NF-kappaB activation and inflammatory cytokine expression by targeting TAB2, TAB3 and IKK-alpha. PMID: 22660635
    12. human TAB2 and TAB3, ubiquitin-chain sensory proteins involved in NF-kappaB signalling, are directly inactivated by enteropathogenic Escherichia coli NleE, a conserved bacterial type-III-secreted effector responsible for blocking host NF-kappaB signalling PMID: 22158122
    13. These results point to the existence of an autophagy-stimulatory 'switch' whereby TAB2 and TAB3 abandon inhibitory interactions with Beclin 1 to engage in a stimulatory liaison with TAK1. PMID: 22081109
    14. TAB3 is involved in IL-1-induced NF-kappaB activation by physically linking TAK1 to TRAF6. PMID: 14633987
    15. Identification of TAB3 as a binding partner of the protein kinase TAK1. PMID: 14670075
    16. TAB3 transforming growth factor is a constituent of the NF-kappaB pathway functioning upstream of tumor necrosis factor alpha-associated factor 6/transforming growth factor beta-activated kinase PMID: 14766965
    17. Data show that TAB2 and TAB3 are receptors that bind preferentially to polyubiquitin chains through a highly conserved zinc finger (ZnF) domain, and activate NF-kappa B and IKK. PMID: 15327770
    18. The TAB2/TAB3 interaction with TAK1 is crucial for the activation of signaling cascades mediated by interleukin-1, tumor necrosis factor, and receptor activator of nuclear factor-kappa B ligand (RANKL). PMID: 17158449

    显示更多

    收起更多

  • 组织特异性：
    Widely expressed. Constitutively overexpressed in certain tumor tissues.; [Isoform 1]: Major transcript.; [Isoform 2]: Minor transcript.
  • 数据库链接：

    HGNC: 30681

    OMIM: 300480

    KEGG: hsa:257397

    STRING: 9606.ENSP00000288422

    UniGene: Hs.188256