Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. Selenot Antibody

Selenot Antibody

  • 货号：
    CSB-PA350436LA01MO
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Mus musculus (Mouse) Selenot Polyclonal antibody
  • Uniprot No.：
    P62342
  • 基因名：
    Selenot
  • 别名：
    Selenot antibody; Selt antibody; Thioredoxin reductase-like selenoprotein T antibody; SelT antibody; EC 1.8.1.9 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse
  • 免疫原：
    Recombinant Mouse Thioredoxin reductase-like selenoprotein T protein (20-195AA)
  • 免疫原种属：
    Mus musculus (Mouse)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Selenot Antibody (CSB-PA350436LA01MO)，的标记方式是Non-conjugated。对于Selenot Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA350436LB01MO Selenot Antibody, HRP conjugated ELISA
    FITC CSB-PA350436LC01MO Selenot Antibody, FITC conjugated
    Biotin CSB-PA350436LD01MO Selenot Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Selenoprotein with thioredoxin reductase-like oxidoreductase activity. Protects dopaminergic neurons against oxidative stress ans cell death. Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion. Plays a role in fibroblast anchorage and redox regulation. In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation. In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion.
  • 基因功能参考文献：
    1. Selenoprotein T is a novel oligosaccharyltransferase subunit that regulates unfolded protein response signaling and ASTH secretion. PMID: 28928140
    2. SelT exerts a neuroprotective role which is essential during brain development, and that its loss impairs mice behavior. PMID: 26497036
    3. The SelT play a crucial role in the protection of dopaminergic neurons against oxidative stress and cell death, providing insight into the molecular underpinnings of this stress in PD. PMID: 26866473
    4. Data suggest SelT is expressed in pancreatic beta- and delta-cells; inactivation of SelT in beta-cells leads to glucose intolerance via impaired glucose homeostasis and PACAP (pituitary adenylate cyclase-activating polypeptide) insulinotropic effect. PMID: 23913443
    5. Data show that the loss of SelT elevates expression of another selenoprotein, selenoprotein W, suggesting that SepW1 may functionally compensate for SelT. PMID: 19935881

    显示更多

    收起更多

  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族：
    SelWTH family, Selenoprotein T subfamily
  • 组织特异性：
    Ubiquitous. Highly expressed in the endocrine pancreas. Expressed at low levels in the adult brain.
  • 数据库链接：

    KEGG: mmu:69227

    STRING: 10090.ENSMUSP00000103557

    UniGene: Mm.270950