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SYNM Antibody

  • 货号：
    CSB-PA023019LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA023019LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA023019LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SYNM Polyclonal antibody
  • Uniprot No.：
    O15061
  • 基因名：
    SYNM
  • 别名：
    Desmuslin antibody; DMN antibody; KIAA0353 antibody; SYN antibody; SYNEM_HUMAN antibody; Synemin alpha antibody; Synemin antibody; Synemin beta antibody; Synemin; intermediate filament protein antibody; SYNM antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Synemin protein (1147-1417AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SYNM Antibody (CSB-PA023019LA01HU)，的标记方式是Non-conjugated。对于SYNM Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA023019LB01HU SYNM Antibody, HRP conjugated ELISA
    FITC CSB-PA023019LC01HU SYNM Antibody, FITC conjugated
    Biotin CSB-PA023019LD01HU SYNM Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells.
  • 基因功能参考文献：
    1. LMOD1, SYNPO2, PDLIM7, PLN, and SYNM down-regulation reflect the altered phenotype of smooth muscle cells in vascular disease and could be early sensitive markers of SMC dedifferentiation. PMID: 27470516
    2. alpha-Synemin localizes to the M-band of the sarcomere through interaction with the M10 region of titin PMID: 25447537
    3. Immunohistochemistry of synemin in reactive astrocytes and Rosenthal fibers in two patients with Alexander disease. There was an abundance of GFAP-positive Rosenthal fibers and widespread reactive gliosis in the white matter and subpial regions. PMID: 23594359
    4. synemin positively regulates glioblastoma cell proliferation by helping sequester PP2A away from Akt, thereby favoring Akt activation. PMID: 22337773
    5. Synemin knock-down did not influence the cytoskeleton expression and organization of human Chang liver cells PMID: 21144834
    6. SYNM could represent a novel putative breast tumor suppressor gene that is prone to epigenetic silencing. SYNM promoter methylation may become a useful predictive biomarker to stratify breast cancer patients' risk for tumor relapse. PMID: 20543860
    7. Desmuslin expression is required for the maintenance of vascular smooth muscle phenotype. Decreased desmuslin expression may affect differentiation of VSMCs and ultimately contribute to the development of varicose veins. PMID: 20573469
    8. The differences in human syncoilin and beta-synemin mRNA ratios between Duchenne muscular dystrophy and normal muscles were not statistically significant PMID: 20199207
    9. The LIM domain protein zyxin was identified as an interaction partner for human synemin. PMID: 19853601
    10. Genomic organization and single-nucleotide polymorphism map of desmuslin, a novel intermediate filament protein on chromosome 15q26.3. PMID: 11454237
    11. Expression of the intermediate filament protein synemin in myofibrillar myopathies and other muscle diseases. PMID: 12669240
    12. the default of KIAA0353 gene may play a role in the occurrence and development of varicose great saphenous vein in PDVI patients. PMID: 12887813
    13. The colocalization of Synemin [syn] with vimentin, GFAP, or neurofilament supports the idea that Syn is a key cross-linking protein in morphogenesis that connects different cytoskeletal structures PMID: 14552890
    14. Based on its localization and its expression pattern, beta-synemin functions as a structural protein involved in maintaining muscle integrity through its interactions with alpha-dystrobrevin, desmin, and other structural proteins. PMID: 15318345
    15. synemin is associated with ruffled membranes in addition to being distributed along the intermediate filament network PMID: 15657940
    16. Desmuslin is down-regulated in incompetent saphenous veins. PMID: 16476617
    17. Mammalian synemin is also shown to colocalize with dystrophin within muscle cell cultures PMID: 16777071
    18. The stability of DMN was analyzed under the action of low-level laser therapy. PMID: 17564317
    19. alpha-synemin, but not beta-synemin, interacts with both vinculin and metavinculin PMID: 18028034
    20. results revealed that synemin was modulated nearly in all human human hepatocellular carcinoma cases PMID: 18084875
    21. Results suggest human alpha-synemin plays an essential role in linking the heteropolymeric intermediate filament to adherens-type junctions, such as the costameres within mammalian striated muscle cells, via its interaction with talin. PMID: 18342854

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell junction, adherens junction. Note=There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z-lines, and another in which it interacts with both DTNA and DES at the costamere.
  • 蛋白家族：
    Intermediate filament family
  • 组织特异性：
    Isoform 2 is strongly detected in adult heart, fetal skeletal muscles and fetal heart. Isoform 1 is weakly detected in fetal heart and also in fetal skeletal muscle. Isoform 1 and isoform 2 are detected in adult bladder (at protein level). The mRNA is pre
  • 数据库链接：

    HGNC: 24466

    OMIM: 606087

    KEGG: hsa:23336

    STRING: 9606.ENSP00000336775

    UniGene: Hs.207106