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SYNE3 Antibody

  • 货号：
    CSB-PA007644
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Jurkat cells using Nesprin-3 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q6ZMZ3
  • 基因名：
    SYNE3
  • 别名：
    C14orf49 antibody; Chromosome 14 open reading frame 49 antibody; FLJ25605 antibody; MGC75267 antibody; Nesp3 antibody; Nesprin 3 antibody; Nesprin-3 antibody; NET53 antibody; Nuclear Envelope Spectrin Repeat Protein 3 antibody; Spectrin Repeat Containing, Nuclear Envelope Family Member 3 antibody; SYNE3 antibody; SYNE3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Nesprin-3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.
  • 基因功能参考文献：
    1. SPAG4, in cooperation with Nesprin3, has a fundamental pathological function in the migration of lung carcinoma cells. PMID: 29901114
    2. Overexpression of LINC00341 suppresses the expression of vascular cell adhesion molecule 1 (VCAM1) and the adhesion of monocytes induced by atheroprone flow and tumor necrosis factor-alpha. PMID: 28500253
    3. Meta-analysis estimated the relationship between LINC00341 expression and distant metastasis or lymph node metastasis in breast cancer. PMID: 28146429
    4. nesprin-3 regulates vascular endothelial cell shape, perinuclear cytoskeletal architecture, and important aspects of flow-mediated mechanotransduction. PMID: 21937718
    5. association with human nesprin-3 appeared to be stronger for torsinADeltaE than for torsinA. TorsinA also associated with the KASH domains of nesprin-1 and -2 PMID: 18827015

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  • 亚细胞定位：
    Nucleus outer membrane; Single-pass type IV membrane protein. Nucleus envelope. Rough endoplasmic reticulum.
  • 蛋白家族：
    Nesprin family
  • 组织特异性：
    Expressed in aortic endothelial cells (at protein level).
  • 数据库链接：

    HGNC: 19861

    OMIM: 610861

    KEGG: hsa:161176

    STRING: 9606.ENSP00000334308

    UniGene: Hs.354645