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SWAP70 Antibody

  • 货号：
    CSB-PA887026LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: SWAP70 antibody at 10µg/ml
      Lane 1: NIH/3T3 whole cell lysate
      Lane 2: HepG2 whole cell lysate
      Lane 3: Raji whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 69 kDa
      Observed band size: 69 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SWAP70 Polyclonal antibody
  • Uniprot No.：
    Q9UH65
  • 基因名：
    SWAP70
  • 别名：
    KIAA0640 antibody; 70kDa antibody; AV235546 antibody; FLJ39540 antibody; HSPC321 antibody; SWA 70 protein antibody; SWAP 70 antibody; SWAP switching B-cell complex 70kDa subunit antibody; SWAP-70 antibody; SWAP70 antibody; Switch associated protein 70 antibody; Switch-associated protein 70 antibody; SWP70_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Switch-associated protein 70 protein (1-300AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SWAP70 Antibody (CSB-PA887026LA01HU)，的标记方式是Non-conjugated。对于SWAP70 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA887026LB01HU SWAP70 Antibody, HRP conjugated ELISA
    FITC CSB-PA887026LC01HU SWAP70 Antibody, FITC conjugated
    Biotin CSB-PA887026LD01HU SWAP70 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
  • 基因功能参考文献：
    1. Expression of switch-associated protein 70 is associated with lymphocyte activation and reduced disability in multiple sclerosis. PMID: 27495372
    2. These data show a key role for SWAP70 as a scaffold for tethering the peripheral actin cage to phagosomes. PMID: 27806292
    3. SWAP70 appears to act as a molecular intermediate between vGPCR and endothelial activation. PMID: 25889342
    4. SWAP70 may be a target of miR-145, and it might have a potential oncogenic function. PMID: 21360565
    5. Detection of SWAP70 antibodies during the attack period might suggest that SWAP70 is involved in Multiple Sclerosis relapse pathogenesis PMID: 22728961
    6. The unwinding of the C-terminal alpha-helix could regulate the functions of SWAP-70 at the plasma membrane surface. PMID: 22247562
    7. findings suggest that regulation of eosinophil trafficking and migration by SWAP-70 is important for the development of eosinophilic inflammation after allergen exposure PMID: 22210919
    8. protein that functions as the only B cell-specific component of an isotype switch recombination PMID: 11726218
    9. Overexpression of SWAP-70 altered the actin organization and lamellipodial morphology PMID: 12925760
    10. the binding activity of SWAP-70 to non-muscle F-actin is required for membrane ruffling. PMID: 16418221
    11. surface expression of SWAP-70 on HIV-1 infected cells as well as PBMCs; SWAP-70 may serve as a marker for T cell differentiation as well as for HIV-1 infection PMID: 16547421
    12. SWAP-70 may be involved in regulating migration and invasion of trophoblast cells during the processes of embryonic implantation and placentation in primates. PMID: 17371938

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  • 亚细胞定位：
    Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium. Cytoplasm, cytoskeleton.
  • 组织特异性：
    Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue. Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages.
  • 数据库链接：

    HGNC: 17070

    OMIM: 604762

    KEGG: hsa:23075

    STRING: 9606.ENSP00000315630

    UniGene: Hs.153026