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SUPT20H Antibody

  • 货号：
    CSB-PA394854
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of mouse-kidney cells using Antibody diluted at 1000
  • 其他：

产品详情

  • Uniprot No.：
    Q8NEM7
  • 基因名：
  • 别名：
    AA667204 antibody; AI450544 antibody; bA421P11.4 antibody; C13 antibody; C13orf19 antibody; D3Ertd300e antibody; FA48A_HUMAN antibody; FAM48A antibody; FP757 antibody; p38-interacting protein antibody; p38IP antibody; Protein FAM48A antibody; RGD1307812 antibody; SPT20 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide from AA range: 231-280
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB,ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-10000ELISA:1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy.
  • 基因功能参考文献：
    1. provide the first report that p38-p38IP is required for the Snail-induced E-cadherin down-regulation and cell invasion in HNSCC PMID: 27531877
    2. p38IP inhibits ubiquitination-induced GCN5 degradation and therefore promotes alpha-tubulin acetylation, facilitating spindle formation and G2/M progression. PMID: 24220028
    3. hSPT20 and other hSAGA subunits, together with RNA polymerase II, are specifically recruited to genes induced by endoplasmic reticulum (ER) stress. PMID: 19114550
    4. Manipulation of p38IP and p38alpha alters mAtg9 localization, suggesting p38alpha regulates, through p38IP, the starvation-induced mAtg9 trafficking to forming autophagosomes. PMID: 19893488
    5. Novel transcription factors identified in human CD34 antigen-positive hematopoietic stem cells. PMID: 12070015
    6. C13orf19 mRNA is down-regulated in matched prostate tissues compared to prostate carcinoma tissues PMID: 15978328
    7. C13orf19 is expressed independently of the androgen. No interaction between C13orf19 and p38MAPK was identified. PMID: 16685401
    8. mRNA is down-regulated in human prostate cancer, also described as C13 PMID: 11340631

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    SPT20 family
  • 组织特异性：
    Highly expressed in testis, moderately in brain and pituitary gland. Expressed in several fetal tissues, including lung, brain, thymus and kidney. Expression is down-regulated in malignant prostate tissues.
  • 数据库链接：

    HGNC: 20596

    OMIM: 613417

    KEGG: hsa:55578

    STRING: 9606.ENSP00000218894

    UniGene: Hs.435815