SULT2A1 Antibody

1. Kinetic analyses showed further differential catalytic efficiency and substrate affinity of the SULT2A1 allozymes, in comparison with wild-type SULT2A1. These findings provided useful information concerning the effects of genetic polymorphisms on the sulfating activity of SULT2A1 allozymes. PMID: 29671343
2. Polymorphisms of SULT2A1 gene is not associated with attention-deficit/hyperactivity disorder. PMID: 28367959
3. nine human SULT2A1 allozymes plus the wild-type SULT2A1 were found to display differential sulfating activity toward DHEA and tibolone. Kinetic analysis revealed that different SULT2A1 allozymes exhibited differential substrate affinity and catalytic efficiency toward the two substrates tested. PMID: 29392568
4. Mass spectrometry analysis and structural modeling supported a reaction mechanism which involves the isomerization of Delta(4)-3-ketosteroids from the keto form to an enol form, prior to being subjected to sulfation. Results derived from this study suggested a potential role of SULT2A1 as a Delta(4)-3-ketosteroid sulfotransferase in steroid metabolism PMID: 28782626
5. A theoretical study at the level of density functional theory (DFT) was performed to characterize noncovalent intermolecular interactions, especially hydrogen bond interactions, in the active site of enzyme human androsterone sulphotransferase. PMID: 27337388
6. Decreased SULT2A1 activity was found in the adrenal zona reticularis in Alzheimer's disease patients. PMID: 26680489
7. PSC is characterized by disease-specific impairment of SULT2A1 expression following PXR activation, a phenomenon which is not noted in PBC, and may account for the impaired hepatoprotection in PSC. PMID: 26504856
8. It metabolizes breast cancer drugs like afinoxifene and endoxifen by sulfation. PMID: 26169578
9. The substrate, such as lithocholic acid (LCA), participated in regulating the structure and flexibility of sulfotransferase actively rather than merely being selected passively. PMID: 26149755
10. Our results show that SULT2A1 is important in the first trimester; particularly in the adrenals PMID: 25802089
11. molecular dynamic simulations were used to investigate the effect of ligands (cofactor and substrate) on the thermo-denaturation process of hSULT2A1 PMID: 25750022
12. results established human SULT2A1 as a novel LXRalpha target gene; the expression of LXRalpha is a potential predictor for the expression of SULT2A1 in human liver PMID: 25028566
13. It turns out the protective effect of DHEA was significantly decreased when Wnt/beta-catenin signaling was activated, while inactivating Wnt/beta-catenin signaling enhanced the effects of DHEA PMID: 25065588
14. The complete kinetic mechanism of human SULT2A1. PMID: 25056952
15. Fetal inflammatory response syndrome and funisitis are associated with an elevation of umbilical cord plasma concentrations of soluble sulfotransferase (ST)2. PMID: 23488731
16. Depression following hip fracture with poor long term recovery is associated with a higher serum cortisol:DHEAS ratio. PMID: 23773910
17. Genetic variants in SULT2A1 do not predispose to polycystic ovary syndrome. Although a variant in SULT2A1 decreased the DHEAS to DHEA ratio, no changes in other androgenic hormone levels were observed. PMID: 23861462
18. formation of disulfide bonds in hSULT2A1 is a potentially important reversible mechanism for alterations in the rates of sulfation of both endogenous and xenobiotic substrates PMID: 23444386
19. These data show an age-related association of polymorphisms in the SULT2A1 gene with lower dehydroepiandrosterone sulfate, suggesting that these polymorphisms may affect dehydroepiandrosterone sulfate concentration in adults. PMID: 23436881
20. SULT2A1 as a novel ROR-alpha and ROR-gamma target gene. PMID: 23211525
21. Genetic variants of SULT2A1 do not appear to have an effect on individual DHEA and DHEAS concentrations or the DHEA/DHEAS ratio as a marker of DHEA sulfonation capacity PMID: 23132913
22. A crystallographic and biochemical description of the molecular linkages that couple nucleotide binding and SULT2A1 isomerization. PMID: 23362278
23. The simulations predict that the active-site "cap," which covers both the nucleotide and acceptor binding sites, opens and closes in response to nucleotide. PMID: 23256751
24. Common polymorphisms at POR, SULT2A1 or HSD11B1 were not associated with PA in a Finnish Caucasian population. PMID: 22445027
25. Serum DHEAS levels are increased in patients with non-alcoholic fatty liver disease with elevated alanine aminotransferase levels. PMID: 21841322
26. Hydroxysteroid sulfotransferase SULT2A1 is suppressed by the estrogen related receptor alpha PMID: 21513704
27. The sulfation kinetics of dehydroepiandrosterone and 15 human bile acids by SULT2A1, was characterized. PMID: 20102295
28. Crystal structure of human dehydroepiandrosterone sulphotransferase in complex with substrate PMID: 11988089
29. Both steroidogenic factor 1 and GATA-6 were positive regulators of SULT2A1 promoter constructs PMID: 15388788
30. lowered expression in hepatocellular carcinoma tissues involved in metabolism and/or inactivation of sex steroids is consistent with a regulatory role SULT2A1 in the development and/or tumor cell differentiation and progression of human HCC PMID: 15713538
31. Estrogen receptor alphaeffects on SULT2A1 were greater than the stimulation seen in response to steroidogenic factor 1 (SF1). PMID: 15878968
32. The SULT2A1 is the major endogenous enzyme responsible for sulfation of the tibolone metabolites in human postmenopausal tissues. PMID: 16360722
33. the SULT2A1 gene is mediated by SF1 and indirectly regulated by T(3) PMID: 16469813
34. No significant association of the presence of the different SULT2A1 alleles with the occurrence of prostate cancer in black men was detected. PMID: 16617014
35. Methotrexate induction of hSULT2A1 is mediated through hCAR. PMID: 17276571
36. genetic evidence suggesting a potential role of SULT2A1, but not STS, in the inherited adrenal androgen excess of polycystic ovary syndrome PMID: 17426092
37. Two amino acids are identified and characterized for the substrate inhibition of SULT2A1. PMID: 18042734
38. In cortices attached to adrenocortical adenomas, SULT2A1 mRNA expression was present mainly in zona reticularis and extended to zona fasciculata. PMID: 18505908
39. Sulfation of polychlorinated phenols catalyzed by hSULT2A1 may be a significant component of their metabolism in humans. PMID: 18656962
40. Testosterone and insulin appear to be modulators of adrenal androgen production in this human adrenocortical cell model. PMID: 18684447
41. Demonstrate that hSULT2A1 is responsible for the N-sulfation of quinolones and possibly other therapeutic drugs in humans. PMID: 19420132

显示更多

收起更多

HGNC: 11458

OMIM: 125263

KEGG: hsa:6822

STRING: 9606.ENSP00000222002

UniGene: Hs.515835