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STXBP3 Antibody

  • 货号：
    CSB-PA022907ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: STXBP3 antibody at 10μg/ml
      Lane 1: HepG2 whole cell lysate
      Lane 2: K562 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 68 kDa
      Observed band size: 68 kDa
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA022907ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) STXBP3 Polyclonal antibody
  • Uniprot No.：
    O00186
  • 基因名：
    STXBP3
  • 别名：
    Munc18 3 antibody; Munc18 c antibody; Platelet Sec1 protein antibody; Protein unc-18 homolog 3 antibody; Protein unc-18 homolog C antibody; PSP antibody; STXB3_HUMAN antibody; STXBP 3 antibody; STXBP3 antibody; Sxtbp3 antibody; syntaxin 4 binding protein antibody; Syntaxin binding protein 3 antibody; Syntaxin-binding protein 3 antibody; Unc 18 3 antibody; Unc 18 homolog 3 antibody; Unc 18c antibody; Unc-18C antibody; Unc18-3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Syntaxin-binding protein 3 protein (343-592AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.
  • 基因功能参考文献：
    1. PP2B-Aalpha-Munc18c complex supports agonist-induced VWF secretion by HUVECs. PMID: 28294518
    2. Munc18c gene expression in human adipose tissue is down-regulated in morbid obesity. PMID: 23700440
    3. Western Blot data showed decreased expression (p < 0,05) of Munc18c and phospho-PKC Zeta in polycystic ovary-insulin resistant endometria (PCOSE-IR) with respect to the control. PMID: 22390153
    4. The identify IR as the first known tyrosine kinase for Munc18c as part of a new insulin-signaling step in GLUT4 vesicle exocytosis. PMID: 21444687
    5. Calpha activation and phosphorylation of syntaxin 4 and Munc18c are required for the cell surface expression of P-selectin and the consequent binding of neutrophils to endothelial cells. PMID: 15576373
    6. These results indicate that insulin induces dynamic associations between PKCzeta, 80K-H, and munc18c and that 80K-H may act as a key signaling link between PKCzeta and munc18c in live cells. PMID: 19061073

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  • 亚细胞定位：
    Cytoplasm, cytosol. Cell membrane. Note=In platelets, predominantly cytosolic. Low amounts membrane-associated.
  • 蛋白家族：
    STXBP/unc-18/SEC1 family
  • 组织特异性：
    Megakaryocytes and platelets.
  • 数据库链接：

    HGNC: 11446

    OMIM: 608339

    KEGG: hsa:6814

    STRING: 9606.ENSP00000359025

    UniGene: Hs.530436