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STX5 Antibody

  • 货号：
    CSB-PA619754ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA619754ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) STX5 Polyclonal antibody
  • Uniprot No.：
    Q13190
  • 基因名：
    STX5
  • 别名：
    OTTHUMP00000185028 antibody; SED5 antibody; STX5 antibody; STX5_HUMAN antibody; STX5A antibody; Syntaxin 5 antibody; Syntaxin 5A antibody; Syntaxin-5 antibody; Syntaxin5 antibody; Syntaxin5A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Syntaxin-5 protein (55-355AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus.
  • 基因功能参考文献：
    1. Expression of the Syn5 K270R mutant in cells impairs post-mitotic Golgi reassembly PMID: 27404360
    2. Together, these data strongly suggest that syntaxin 5-mediated retrograde transport to the Golgi apparatus is a broadly conserved feature of adeno-associated virus trafficking. PMID: 25410859
    3. Stx5 might play a role in modulating VLDL-R physiology by participating in an abrasively described or completely novel Golgi-bypass pathway. PMID: 23701949
    4. serum anti-STX5 autoantibody, which was discovered by a proteomic approach, is a potential new serum marker for the diagnosis of endometriosis. PMID: 21715015
    5. Depletion of syntaxin-5 complex components results in the accumulation of autophagosomes as a result of lysosomal dysfunction, leading to decreased degradation of autophagic substrates. PMID: 21242315
    6. Syx5 is required for the maintenance of the Golgi structures but may not play a major role in the transport of vesicles carrying proteins between the ER and the Golgi compartment. PMID: 16081076
    7. hypothesize that syntaxin 5 also has trafficking-independent functions PMID: 17389686
    8. depletion of GM130 by RNA interference slows the rate of ER to Golgi trafficking in vivo; interactions of GM130 with syntaxin 5 and Rab1 are regulated by mitotic phosphorylation PMID: 18167358
    9. Study shows that the SM protein, Sly1, interacts directly with the conserved oligomeric Golgi (COG) tethering complex; Sly1-COG interaction is mediated by the Cog4 subunit, which also interacts with Syntaxin 5 through a different binding site. PMID: 19536132

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  • 亚细胞定位：
    Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type IV membrane protein. Golgi apparatus membrane.
  • 蛋白家族：
    Syntaxin family
  • 数据库链接：

    HGNC: 11440

    OMIM: 603189

    KEGG: hsa:6811

    STRING: 9606.ENSP00000294179

    UniGene: Hs.654602