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STOML2 Antibody

  • 货号：
    CSB-PA892131ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA892131ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA892131ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) STOML2 Polyclonal antibody
  • Uniprot No.：
    Q9UJZ1
  • 基因名：
  • 别名：
    EPB72 like protein 2 antibody; EPB72-like protein 2 antibody; HSPC108 antibody; OTTHUMP00000021320 antibody; Paraprotein target 7 antibody; Paratarg 7 antibody; SLP 2 antibody; SLP-2 antibody; SLP2 antibody; STML2_HUMAN antibody; Stomatin (EPB72) like 2 antibody; Stomatin like 2 antibody; Stomatin like protein 2 antibody; Stomatin like protein 2, mitochondrial antibody; Stomatin-like protein 2 antibody; STOML2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Stomatin-like protein 2, mitochondrial protein (29-356AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation.
  • 基因功能参考文献：
    1. TROP-2, SLP-2 and CD56 were effective diagnostic markers for PTC, especially when they were combined to use. PMID: 29951933
    2. Data show that SLP-2 is upregulated by high cisplatin concentrations, leading to increased protein turnover. Overexpression of SLP-2 activates the MEK/ERK signaling pathway, and suppresses the mitochondrial apoptosis pathway, indicating that SLP-2 inhibits apoptosis by activating the MEK/ERK pathway and inhibiting the mitochondrial apoptosis pathway in cervical cancer cells. PMID: 29516570
    3. The expression of STOML2, a gene that plays a key role in mitochondrial function and T-cell activation, is associated with both IL-6 signaling and asthma risk. PMID: 26932604
    4. results reveal an important role of SLP2 membrane scaffolds for the spatial organization of inner membrane proteases regulating mitochondrial dynamics, quality control, and cell survival. PMID: 27737933
    5. Slp2 is involved in endometrial stromal cell proliferation and differentiation during decidualization in mice and humans PMID: 27986413
    6. The significant association of SLP-2 overexpression with unfavorable clinicopathological characteristics and BRAFV600E mutation indicates that SLP-2 may have a role in aggressiveness of BRAF-mutated papillary thyroid carcinoma. PMID: 26750533
    7. Stomatin-like protein 2 is overexpressed in epithelial ovarian cancer and predicts poor patient survival PMID: 26487491
    8. STOML2 was correlated to progression in cervical cancer, and implicated it as a potential predictive factor for the prognosis of cervical cancer. PMID: 25973071
    9. Our study showed that STOML-2 was negatively regulated by miR1207-5p in esophageal carcinoma PMID: 25695396
    10. SLP-2 was upregulated by TGF-beta1, indicating a possible role of SLP-2 in Papillary thyroid cancer tumorigenesis. PMID: 24190591
    11. STOML2 may have a role in progression of gastric adenocarcinoma PMID: 24258357
    12. Increased levels of SLP-2 correlate with lymph node metastasis in gastric cancer. PMID: 23371255
    13. SLP-2 may play an important role in human GBC tumorigenesis, and SLP-2 might serve as a novel prognostic marker in human GBC. PMID: 23918306
    14. Expression of SLP-2 is associated with invasion of esophageal squamous cell carcinoma. PMID: 23667687
    15. SLP-2 deficiency in T-lymphocytes is associated with abnormal cardiolipin compartmentalization in mitochondrial membranes, defects associated with altered mitochondrial respiration that is increasingly uncoupled from ATP production. PMID: 23028053
    16. [review] Stomatin family member STOML2 is oligomeric; it localizes mostly to membrane domains and has been shown to modulate ion channel activity. PMID: 21501885
    17. SLP-2 facilitates the compartmentalization not only of mitochondrial membranes but also of the plasma membrane into functional microdomains. PMID: 22623988
    18. investigation of biomarkers for early diagnosis of endometriosis: Data suggest that SLP2, tropomyosin 3, and tropomodulin 3 are autoantigens present in blood of women with endometriosis; immunodominant epitopes were identified. PMID: 22158085
    19. SLP-2 and HER2/neu can play a role in lymph node/distant metastases of breast cancers PMID: 22081131
    20. We propose that the function of SLP-2 is to recruit prohibitins to cardiolipin to form cardiolipin-enriched microdomains in which electron transport complexes are optimally assembled. PMID: 21746876
    21. plasma concentrations of stomatin (EPB72)-like 2 in early-stage colorectal cancer patients were elevated as compared with those of healthy individuals PMID: 21209152
    22. The dominant inheritance of hyperphosphorylated paratarg-7 explains cases of familial IgM monoclonal gammopathy of undetermined significance and Waldenstrom macroglobulinemia PMID: 21220746
    23. negatively modulates mitochondrial sodium-calcium exchange PMID: 19944461
    24. SLP-2 overexpression is associated with tumour distant metastasis and poor prognosis in pulmonary squamous cell carcinoma. PMID: 19839737
    25. overexpression of stomatin-like protein 2 is associated with neoplasms PMID: 16533792
    26. SLP-2 is a high abundance protein in several tissues and cells and may play an important biological role; this study uses mass spectrometry to analyze its primary structure PMID: 16671055
    27. SLP-2 was overexpressed in endometrial adenocarcinoma compared with their normal counterparts. PMID: 17342323
    28. High-level SLP-2 expression was associated with decreased overall survival (P = .011) and was more often found in patients with tumors larger than 20 mm, lymph node metastasis, advanced clinical stage, distant metastasis PMID: 17709317
    29. SLP-2 is an important player in T cell activation by ensuring sustained TCR signaling PMID: 18641330
    30. Familial MGUS and multiple myeloma were associated with a dominant inheritance of hyperphosphorylated paratarg-7 PMID: 19767238
    31. Endosymbiotic origin of paraslipin from an alphaprotoebacterial ancestor (SLP-2) PMID: 18267007

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein. Mitochondrion. Mitochondrion inner membrane; Lipid-anchor. Mitochondrion intermembrane space. Membrane raft. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Band 7/mec-2 family
  • 组织特异性：
    Ubiquitously expressed at low levels. Expressed in lymphoid tissues (at protein level).
  • 数据库链接：

    HGNC: 14559

    OMIM: 608292

    KEGG: hsa:30968

    STRING: 9606.ENSP00000348886

    UniGene: Hs.3439