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STOM Antibody

  • 货号：
    CSB-PA022862ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Erythrocyte band 7 integral membrane protein antibody at 5μg/ml + Mouse liver tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 32, 14 kDa
      Observed band size: 32 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA022862ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA022862ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) STOM Polyclonal antibody
  • Uniprot No.：
    P27105
  • 基因名：
  • 别名：
    BND7 antibody; EPB7 antibody; EPB72 antibody; Erythrocyte band 7 integral membrane protein antibody; Erythrocyte membrane protein band 7.2 (stomatin) antibody; Erythrocyte surface protein band 7.2 antibody; Protein 7.2b antibody; STOM antibody; STOM_HUMAN antibody; Stomatin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Erythrocyte band 7 integral membrane protein (55-288AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.
  • 基因功能参考文献：
    1. we show that stomatin modulates the transport activity of AE1 through a direct protein-protein interaction. PMID: 28387307
    2. These results may suggest that stomatin is a new prognostic indicator for HER2-positive breast cancer PMID: 27577936
    3. FRAP analyses indicate that the stomatin C-terminus is the dominant entity for lateral mobility and binding site for the cortical actin cytoskeleton PMID: 28575093
    4. This study showed that cells expressing more stomatin or exposed to exogenous stomatin are more prone to undergoing cell fusion; during osteoclastogenesis, depletion of stomatin inhibited cell fusion but had little effect on tartrate-resistant acid phosphatase production. PMID: 27663861
    5. s took a proteomic approach to identify stomatin, a member of the integral proteins of lipid rafts, as a cellular protein interacting with hepatitis C virus NS5B. PMID: 25262680
    6. Stomatin protein expression is down-regulated in 80% of non-small cell lung cancer samples. PMID: 24533441
    7. upregulation of stomatin by hypoxia and dex may enhance the barrier function of alveolar epithelia and mediate the adaptive role of glucocorticoid to hypoxia PMID: 23672602
    8. Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains PMID: 23219802
    9. [review] Stomatin family member STOM is oligomeric; it localizes mostly to membrane domains and has been shown to modulate ion channel activity. PMID: 21501885
    10. The study indicates that stomatin, sorcin, and synexin are echinophilic membrane components that mainly locate outside GM1 rafts in the human erythrocyte membrane. PMID: 20858460
    11. This study demonstrated the existence of alpha-granular lipid rafts and suggests an important role for stomatin in the organization and function of alpha granules. PMID: 12130500
    12. stomatin is localized to detergent-insoluble domains of neutrophil granule membranes PMID: 12429719
    13. in stomatocytosis there is no significant abnormality in stomatin gene sequence instead, deficiency of stomatin from red cells appears to be due to a loss of stomatin from these red cells on maturation in the bone marrow and in the circulation. PMID: 12750157
    14. study of strongly homologous stomatin-like genes in prokaryotes reveals a close connection with a gene coding for a hydrophobic protein with a probable serine protease motif; stomatin could be a partner protein for a membrane-bound proteolytic process PMID: 15121101
    15. stomatin binds to and alters the gating of acid-sensing ion channels PMID: 15471860
    16. A small C-terminal region of stomatin that is largely hydrophobic (residues 264-272) is crucial for oligomerization, whereas the N-terminal domain (residues 1-20) and the last 12 C-terminal amino acids (residues 276-287) are not essential. PMID: 16766530
    17. The stomatin-actin association is important in maintaining the structure and in modulating the function of stomatin-containing membrane rafts in red cells. PMID: 17961506
    18. Data indicate that a stomatin-specific, raft-based process is involved in storage-associated vesiculation. PMID: 18067507
    19. Stomatin-like protein-1 interacts with stomatin and is targeted to late endosomes PMID: 19696025
    20. Stomatin is a member of an ancient protein family that has extremely well conserved homologues in all three domains of life. PMID: 18267007

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor; Cytoplasmic side. Membrane raft. Melanosome. Cytoplasmic vesicle.
  • 蛋白家族：
    Band 7/mec-2 family
  • 组织特异性：
    Detected in erythrocytes (at protein level). Widely expressed.
  • 数据库链接：

    HGNC: 3383

    OMIM: 133090

    KEGG: hsa:2040

    STRING: 9606.ENSP00000286713

    UniGene: Hs.253903