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STMN3 Antibody

  • 货号：
    CSB-PA004184
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293 cells using Stathmin-3 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9NZ72
  • 基因名：
    STMN3
  • 别名：
    AI604839 antibody; R75323 antibody; RP23-83A14.1 antibody; SCG10-like protein antibody; Scgn10 like protein antibody; Sclip antibody; Stathmin like 3 antibody; Stathmin-3 antibody; STMN3 antibody; STMN3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Stathmin-3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.
  • 基因功能参考文献：
    1. our findings demonstrate that SCLIP plays an important role in glioma pathology, and may represent a novel therapeutic strategy against human glioma. PMID: 25511414
    2. Overexpression of ID1 in two different cell lines induced STMN3 and GSPT1 at the transcriptional level, while depletion of ID1 reduced their expression. PMID: 25028095
    3. We found that reduced expression and possibly posttranslational modification of SCLIP following paclitaxel treatment impaired the microtubule-destabilizing effect of SCLIP PMID: 23543364
    4. Specific serine-proline phosphorylation and glycogen synthase kinase 3beta-directed subcellular targeting of stathmin 3/Sclip in neurons PMID: 22577147
    5. Studies suggest that a STAT3-SCLIP interaction is required to preserve SCLIP stability and contributes to the maintenance of normal epithelial morphology. PMID: 19824884
    6. The substantial expression of SCLIP in most tissues points out a novel function outside the nervous system and raises the possibility that its coexpression with stathmin could provide some degree of functional redundancy. PMID: 12676564

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  • 亚细胞定位：
    Golgi apparatus. Cell projection, growth cone. Cell projection, axon. Cytoplasm, cytosol.
  • 蛋白家族：
    Stathmin family
  • 组织特异性：
    Neuron specific.
  • 数据库链接：

    HGNC: 15926

    OMIM: 608362

    KEGG: hsa:50861

    STRING: 9606.ENSP00000359070

    UniGene: Hs.639609