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STK25 Antibody

  • 货号：
    CSB-PA022842LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA022842LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA022842LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) STK25 Polyclonal antibody
  • Uniprot No.：
    O00506
  • 基因名：
    STK25
  • 别名：
    C86992 antibody; Serine/threonine kinase 25 antibody; Serine/threonine kinase 25 (STE20 homolog, yeast) antibody; Serine/threonine kinase 25 (STE20 homolog, yeast), isoform CRA_a antibody; Serine/threonine kinase 25 (yeast) antibody; Serine/threonine protein kinase 25 antibody; Serine/threonine-protein kinase 25 antibody; SOK 1 antibody; SOK-1 antibody; SOK1 antibody; Ste20 like kinase antibody; Ste20 yeast homolog antibody; Ste20-like antibody; STE20-like kinase antibody; Ste20/oxidant stress response kinase 1 antibody; Sterile 20 (oxidant stress response kinase 1) antibody; Sterile 20/oxidant stress-response kinase 1 antibody; STK25 antibody; STK25_HUMAN antibody; Yeast Sps1/Ste20 related kinase 1 antibody; YSK 1 antibody; YSK1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Serine/threonine-protein kinase 25 protein (1-426AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，STK25 Antibody (CSB-PA022842LA01HU)，的标记方式是Non-conjugated。对于STK25 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA022842LB01HU STK25 Antibody, HRP conjugated ELISA
    FITC CSB-PA022842LC01HU STK25 Antibody, FITC conjugated
    Biotin CSB-PA022842LD01HU STK25 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.
  • 基因功能参考文献：
    1. STK25 regulates lipid partitioning in human liver cells by controlling TAG synthesis as well as lipolytic activity and thereby NEFA release from lipid droplets for beta-oxidation and TAG secretion. PMID: 26553096
    2. Our results suggest that MST4, STK25 and PDCD10 are upregulated in prostate cancer and may play roles in prostate tumorigenesis. PMID: 25550858
    3. This review notes that all 3 human germinal center kinase III genes consist of 12 exons and are ubiquitously expressed. In SOK1 and MST4, exon 1 encodes a 5' untranslated region, but this is not the case for MST3. PMID: 23889253
    4. Down-modulation of STK25, but not STK24, rescued medulloblastoma cells from NGF-induced TrkA-dependent cell death, suggesting that STK25 is part of the death-signaling pathway initiated by TrkA and CCM2. PMID: 22782892
    5. PDCD10 might be a regulatory adaptor required for STK25 functions, which differ distinctly depending on the redox status of the cells that may be potentially related to tumor progression. PMID: 22652780
    6. Significantly higher STK25 levels were observed in the skeletal muscle of type 2 diabetic patients, compared with individuals with normal glucose tolerance. PMID: 22391949
    7. The results of the study results indicate that attenuation of SOK1 enhanced cell migration and lead to changes in the expression of migration-associated proteins such as FAK and GM130. PMID: 21396913
    8. In cultured human endothelial cells, CCM3 and STK25 regulated barrier function in a manner similar to CCM2, and STKs negatively regulated Rho by directly activating moesin. PMID: 20592472
    9. 14-3-3zeta is a specific substrate for YSK1 that localizes to the Golgi apparatus, and potentially links YSK1 signaling at the Golgi apparatus with protein transport. PMID: 15037601
    10. Ste20 family member (MAP4K3) that is required for maximal S6K (S6 kinase)/4E-BP1 [eIF4E (eukaryotic initiation factor 4E) that is required for maximal S6K (S6 kinase). PMID: 17253963
    11. SOK1 entry into the nucleus is important for the cell death response PMID: 18364353

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  • 亚细胞定位：
    Cytoplasm. Golgi apparatus. Note=Localizes to the Golgi apparatus.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 组织特异性：
    Ubiquitously expressed. Highest levels are found in testis, large intestine, brain and stomach followed by heart and lung.
  • 数据库链接：

    HGNC: 11404

    OMIM: 602255

    KEGG: hsa:10494

    STRING: 9606.ENSP00000325748

    UniGene: Hs.516807