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STK24 Antibody

  • 货号：
    CSB-PA00249A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, A375 whole cell lysate, HepG2 whole cell lysate
      All lanes: STK24 antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 50, 48 kDa
      Observed band size: 50 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA00249A0Rb at dilution of 1:100
    • Immunofluorescence staining of Hela cells with CSB-PA00249A0Rb at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) STK24 Polyclonal antibody
  • Uniprot No.：
    Q9Y6E0
  • 基因名：
    STK24
  • 别名：
    epididymis secretory protein Li 95 antibody; HEL-S-95 antibody; Mammalian STE20 like protein kinase 3 antibody; Mammalian STE20-like protein kinase 3 antibody; Mammalian STE20-like protein kinase 3 C-terminal antibody; Mammalian STE20-like protein kinase 3 N-terminal antibody; Mammalian sterile 20-like 3 antibody; MST-3 antibody; MST3/C antibody; MST3/N antibody; MST3B antibody; serine threonine kinase 24 antibody; Serine/threonine kinase 24 (Ste20; yeast homolog) antibody; Serine/threonine-protein kinase 24 12 kDa subunit antibody; Serine/threonine-protein kinase 24 antibody; STE20 homolog yeast antibody; STE20 like kinase MST3 antibody; STE20-like kinase MST3 antibody; Stk24 antibody; STK24_HUMAN antibody; STK3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Serine/threonine-protein kinase 24 protein (1-431AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，STK24 Antibody (CSB-PA00249A0Rb)，的标记方式是Non-conjugated。对于STK24 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA00249B0Rb STK24 Antibody, HRP conjugated ELISA
    FITC CSB-PA00249C0Rb STK24 Antibody, FITC conjugated
    Biotin CSB-PA00249D0Rb STK24 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.
  • 基因功能参考文献：
    1. High MST3 expression is associated with breast cancer. PMID: 26910843
    2. This study demonistrated that MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development. PMID: 25456499
    3. This review notes that in the SOK1 and MST4 germinal center kinase III family of proteins, exon 1 encodes a 5' untranslated region, but this is not the case for MST3. PMID: 23889253
    4. These data provide molecular understanding of the mechanism by which MO25 isoforms regulates the activity of STE20 family protein kinases. PMID: 23296203
    5. results show that a STRADalpha-rac1-PAK1 pathway regulates cell polarity and invasion in LKB1-null cells. It also suggests that while the function of LKB1 and STRADalpha undoubtedly overlap, they may also have mutually exclusive roles PMID: 22493453
    6. mechanism of regulation of MST3 PMID: 22229648
    7. Striatin orchestrates the regulation of Mst3 by PP2A. PMID: 21985334
    8. Mst3 is up-regulated and plays an important role in hypoxia-induced apoptosis of human trophoblasts. PMID: 21277991
    9. five crystal structures of the catalytic domain of MST3 are presented, including a complex with ADP and manganese, a unique cofactor preferred by the enzyme, and a complex with adenine. PMID: 20124694
    10. The mammalian sterile 20-like serine/threonine protein kinase 3 (Mst3) plays an essential role in the staurosporine-induced apoptosis of HeLa cells. PMID: 19782762
    11. Proteolytic activation of Mst3 by caspases. PMID: 12107159
    12. Mst3 contains signals which may cooperate to control the subcellular distribution of Mst3. PMID: 15304321
    13. Activation of NDR2 is a multistep process involving phosphorylation of the hydrophobic motif site Thr444/2 by MST3. PMID: 16314523
    14. MST3 inhibits cell migration in a fashion dependent on autophosphorylation and may regulate paxillin phosphorylation through tyrosine phosphatase PTP-PEST PMID: 17046825
    15. study demonstrated the essential role of Mst3, a human Ste20-like protein kinase, in the oxidative stress-induced apoptosis of trophoblasts of term placenta in normal spontaneous delivery PMID: 18040775
    16. Our results reveal that H2O2-induced MST3-mediated cell death involves suppressing both a JNK survival pathway and up-regulation of HO-1. PMID: 19604147

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 组织特异性：
    Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.
  • 数据库链接：

    HGNC: 11403

    OMIM: 604984

    KEGG: hsa:8428

    STRING: 9606.ENSP00000365730

    UniGene: Hs.508514