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  4. STAT5B Antibody

STAT5B Antibody

  • 货号：
    CSB-PA699319
  • 规格：
    ￥1100
  • 图片：
    • The image is immunohistochemistry of paraffin-embedded Human lymphoma tissue using CSB-PA699319(STAT5B Antibody) at dilution 1/10. (Original magnification: ×200)
    • The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA699319(STAT5B Antibody) at dilution 1/10. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P51692
  • 基因名：
  • 别名：
    Signal transducer and activator of transcription 5B antibody; STA5B_HUMAN antibody; STAT5 antibody; Stat5b antibody; Transcription factor STAT5B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human STAT5B
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:500-1:10000
    IHC 1:10-1:50
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Carries out a dual signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.
  • 基因功能参考文献：
    1. STAT5B germline mutation variants exert dominant-negative effects through distinct pathomechanisms, manifesting in milder clinical growth hormone insensitivity syndrome with general sparing of the immune system. PMID: 29844444
    2. Study investigated whether RGS4 could participate in signalling pathways to regulate neurotropic events. These observations suggest that RGS4 is implicated in opioid dependent neuronal differentiation and neurite outgrowth via a "non-canonical" signaling pathway regulating STAT5B-directed responses. PMID: 28219718
    3. Somatic STAT5B N642H gain-of-function mutation in early onset nonclonal eosinophilia, urticaria, dermatitis, and diarrhea in two young patients. PMID: 27956386
    4. High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia. PMID: 27697773
    5. STAT5 signaling drives antigen restimulation-induced T cell death in effector memory T cells PMID: 29187589
    6. Data show that BACH2 and STAT5B are activated by viral insertions, generating chimeric mRNAs specifically enriched in T regulatory cells favoring their persistence. PMID: 28887441
    7. The findings, specifically frequent mutations of STAT5B, PIK3CD, and the histone methyltransferase SETD2, may help guide translational efforts to target hepatosplenic T-cell lymphoma PMID: 28373165
    8. this study shows that musculin inhibits human T-helper 17 cell response to interleukin 2 by controlling STAT5B activity PMID: 28612433
    9. Molecular interactions of EphA4, growth hormone receptor, Jak2, and STAT5B have been described. PMID: 28686668
    10. All merkel cell carcinoma (MCC) cases with a good outcome expressed pSTAT5B, whereas all MCC cases with a poor outcome did not express pSTAT5B; hence, pSTAT5B expression may be an indicator of positive prognosis in patients with MCC. PMID: 28476799
    11. STAT5b confers gemcitabine chemoresistance and promotes cell adherence and invasiveness in pancreatic cancer cells. PMID: 27035235
    12. STAT5 activation by EGF constitutes an important cascade for the regulation of cell proliferation and invasion in trophoblast cells. PMID: 25862676
    13. MSM decreased the ability of STAT5b to bind the promoter of the HER2 gene. PMID: 26648017
    14. Results confirm that STAT5B is mutated in T-PLL and underscore the potential therapeutical relevance of epigenetic regulator. PMID: 26917488
    15. ABL-N administration induced apoptosis of PC3 cells in a dose-dependent manner, along with the enhanced activity of caspases and increased Bax/Bcl-2 ratio. Expression of KLF5, Stat5b and ICAM-1 was significantly downregulated in PC3 cells. PMID: 26397390
    16. Interference of STAT 5b expression by siRNA targeting enhanced the chemo-sensitivity of gastric cancer cells to gefitinib by promoting mitochondrial pathway-mediated cell apoptosis. PMID: 25997700
    17. Our study also assessed the regulation of signaling molecules implicated in the growth, progression, differentiation, and migration of cancer cells, such as Jak2, STAT5b, insulin-like growth factor-1Rbeta, and their phosphorylation status PMID: 26084564
    18. Statistically significant positive correlation has been found between STAT5B and COX-2, and significant negative correlation between STAT5B and PIAS3. PMID: 25137041
    19. STAT5B mutations in the heterozygous state have a significant negative impact on height ( approximately 3.9 cm). This effect is milder than the effect seen in the homozygous state, with height usually within the normal range. PMID: 26034074
    20. Expression of STAT5B was significantly correlated with astrocytoma tumor grade and Karnofsky Performance Scale score. High expressions of NPM, p-JAK2, and STAT5B were associated with a short survival time. PMID: 25907517
    21. study showed that a common mutation of STAT5B results in constitutive STAT5B phosphorylation, growth factor-independent proliferation in cell-based assays, activation of downstream targets in leukemia cells of children with T-cell acute lymphoblastic leukemia and a higher risk of relapse PMID: 24972766
    22. STAT5b rs2293157 G/T genotype was at increased risk of glioma. Furthermore, rs2293157T allele was more significantly prognostic in patients suffering from glioblastoma compared to other subtypes of gliomas PMID: 24878107
    23. Data indicate no STAT5 transcription factor STAT5B mutation was identified in 65 adult T-cell acute lymphoblastic leukemia (T-ALL) patients, and only one STAT5B N642H mutation was detected in 28 pediatric patients. PMID: 25749351
    24. Results identify miR-134 as a novel RTK-regulated tumor-suppressive hub that mediates RTK and RTK-inhibitor effects on GBM malignancy by controlling KRAS and STAT5B. PMID: 24440911
    25. We report a high frequency of STAT5B and STAT5 mutations in gamma-delta hepatosplenic T-cell lymphoma. PMID: 24947020
    26. Macrophage migration inhibitory factor induced accumulation of mast cells in vivo is associated with activation of STAT5. PMID: 24091309
    27. STAT5B homozygous mutation is responsible for a new growth hormone insensitivity syndrome associated to immunological dysfunction. PMID: 23896798
    28. Data indicate that cyclooxygenase-2 (COX-2) expression is dependent on STAT5 phosphorylation. PMID: 23601296
    29. our data suggest that the CD82/STAT5/IL-10 signaling pathway is involved in the survival of CD34(+)/CD38(-)acute myelogenous leukemia cells PMID: 23797738
    30. SNP rs16967637 in the STAT5 gene was the only SNP associated with Crohn's disease without enteritis; homozygosity for the at-risk allele demonstrated the strongest association with this phenotype; results suggest a role for this SNP in development of inflammatory bowel disease of the large intestine PMID: 23929016
    31. aligned IL-2 regulated genes detected by Affymetrix gene expression microarrays with the STAT5 cistrome identified by chip-on-ChIP analysis in an IL-2-dependent human leukemia cell line, Kit225 PMID: 23451206
    32. STAT5B-RARA positive acute promyelocytic leukemia variant is unresponsive to both all trans retinoic acid and arsenic trioxide. PMID: 23271512
    33. This is the first time somatic STAT5 mutations are discovered in human cancer and further emphasizes the role of STAT family genes in the pathogenesis of large granular lymphocytic leukemia. PMID: 23596048
    34. Human STAT5b A630P mutation, like STAT5b F646S is prone to aggregation, as evidenced by its detection in the insoluble fraction, the presence of dimers and higher-order proto-aggregates. PMID: 23160480
    35. Protein level of the signal transducer and activator of transcription, STAT5b, is transiently decreased at temperatures above 37 degrees C. PMID: 23166650
    36. Data suggest that cross-talk occurs between cAMP/PKA and the IL-2R beta/Jak3/Stat5b cascade in T-cells. PMID: 23341462
    37. High STAT5b expression is associated with tumor growth, angiogenesis, and metastases in pancreatic cancer. PMID: 23097626
    38. No association has been found between the STAT5b rs6503691 (C>T) single nucleotide polymorphisms and myeloproliferative neoplasms. PMID: 23130760
    39. These data suggest that STAT5AB is required for the self-renewal of leukemic stem cells PMID: 23149921
    40. results delineate a novel association of nuclear DeltaEGFR with STAT5b, which promotes oncogenesis and treatment resistance in glioblastoma by direct regulation of anti-apoptotic gene, Bcl-XL PMID: 22729867
    41. results point out to a hitherto undescribed link between STAT5 and oxidative stress and provide new insights into STAT5 functions and their roles in leukemogenesis PMID: 22522791
    42. NR0B2 physically interacted with STAT5 and inhibited STAT5 recruitment on the PEPCK gene promoter. PMID: 22977252
    43. pSTAT5 expression was significantly associated with an increased risk of death and of relapse after achieving complete remission PMID: 22725130
    44. Heterozygous STAT5B mutations, with or without heterozygous IGFALS defects, may be associated with growth hormone insensitivity. PMID: 22678306
    45. STAT5b pathway regulates Hsp90alpha expression under hypoxic conditions PMID: 22552610
    46. Ser-193 phosphorylation is associated with Stat5b proto-oncogenic activity and therefore may serve as a novel therapeutic target for treating hematopoietic malignancies. PMID: 22442148
    47. STAT5 phosphorylation levels of EPO and TPO receptors are elevated in bone marrow cells of patients with paroxysmal nocturnal hemoglobinuria. PMID: 22093990
    48. a novel negative cross talk between the NFAT1- and Stat5-signaling cascades that may affect breast tumor formation, growth, and metastasis PMID: 21964595
    49. Stat5-dependent transcriptional regulation is displaced by strong cytosolic iron starvation status induced by mitochondrial ferritin. PMID: 21712541
    50. Genetic variants in STAT5B are associated with total cholesterol and low-density lipoprotein cholesterol levels among six populations. PMID: 21752895

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  • 相关疾病：
    Growth hormone insensitivity with immunodeficiency (GHII)
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Transcription factor STAT family
  • 数据库链接：

    HGNC: 11367

    OMIM: 245590

    KEGG: hsa:6777

    STRING: 9606.ENSP00000293328

    UniGene: Hs.595276