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  4. STARD13 Antibody

STARD13 Antibody

  • 货号：
    CSB-PA070215
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y3M8
  • 基因名：
    STARD13
  • 别名：
    46H23.2 antibody; ARHGAP37 antibody; Deleted in liver cancer 2 protein antibody; Deleted in liver cancer protein 2 antibody; DLC-2 antibody; DLC2 antibody; GT650 antibody; Rho GTPase activating protein on chromosome 13q12 antibody; Rho GTPase-activating protein antibody; STA13 antibody; STA13_HUMAN antibody; StAR related lipid transfer (START) domain containing 13 antibody; StAR-related lipid transfer protein 13 antibody; StARD13 antibody; START domain-containing protein 13 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human StARD13.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.
  • 基因功能参考文献：
    1. Study elucidated StarD13 messenger RNA as a Competitive endogenous messenger RNA (ceRNA) in regulating migration and invasion of breast cancer cells. MicroRNA-125b was identified to induce metastasis of MCF-7 cells and bind with both StarD13 3'UTR and TP53INP1 3'UTR. Therefore, a ceRNA interaction between StarD13 and TP53INP1 mediated by competitively binding to miR-125b was indicated. PMID: 29146309
    2. Low STARD13 expression is associated with metastasis of breast cancer. PMID: 26985770
    3. miR-125b functions as an oncogene in gastric cancer and represents a new potential therapeutic target for gastric cancer. PMID: 27220320
    4. The tumor suppressor DLC2 and Kif1B are central components of a signaling network that guides spindle positioning, cell-cell adhesion and mitotic fidelity. PMID: 25518808
    5. Dimerization of DLC2 was required for its interaction with GKAP, which, in turn, potentiated GKAP self-association. PMID: 24938595
    6. Study describes STARD13 as a tumor suppressor playing a positive role in cancer motility. PMID: 24627003
    7. The present study further describes the role of StarD13 as a tumor suppressor as well as a Rho GAP. PMID: 24253896
    8. Importance of the regulation of RhoA activity in focal adhesions of astrocytoma cells and StarD13 is a GAP playing a major role in this process. PMID: 24333506
    9. In the present review, we discuss the family of RhoGTPases, their regulation and their RhoGAPs, focusing mainly on STARD13. [review] PMID: 23316797
    10. RhoGAP protein Stard13 is an essential regulator of pancreas tissue architecture in the mammalian embryo; Stard13 acts by regulating Rho signalling spatially and temporally during pancreas development. PMID: 23175628
    11. s detected an increase in p-ERK in StarD13 knockdown cells, uncovering a potential link between Rho GTPases and ERK activation. PMID: 22614672
    12. role of miR-125b in pro-metastasis by targeting STARD13 PMID: 22693547
    13. DLC2 inhibits the activity of Raf-1-ERK1/2-p70S6K via its RhoGAP function, resulting in the suppression of cell growth. PMID: 20629949
    14. has GAP activity specific for RhoA and Cdc42; inhibits the Rho mediated assembly of actin stress fibers in cultured cells and is underexpressed in hepatocellular carcinoma tissues PMID: 12531887
    15. underexpression is associated with poor prognosis in patients with hepatocellular carcinoma PMID: 18651974

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  • 亚细胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet.
  • 组织特异性：
    Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.
  • 数据库链接：

    HGNC: 19164

    OMIM: 609866

    KEGG: hsa:90627

    STRING: 9606.ENSP00000338785

    UniGene: Hs.156551