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STAG1 Antibody

  • 货号：
    CSB-PA022785GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8WVM7
  • 基因名：
  • 别名：
    Cohesin subunit SA 1 antibody; Cohesin subunit SA-1 antibody; Cohesin Subunit SA1 antibody; Nuclear protein stromal antigen 1 antibody; SA 1 antibody; SCC 3 homolog 1 antibody; Scc3 antibody; SCC3 homolog 1 antibody; STAG 1 antibody; stag1 antibody; STAG1_HUMAN antibody; Stromal antigen 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human STAG1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
  • 基因功能参考文献：
    1. The SNP but not wild-type had profound alterations in SA-1 expression with miR-29b inhibitor. PMID: 29471289
    2. Here the s demonstrate that the most frequently mutated subunit of the cohesin complex, STAG2, displays a strong synthetic lethal interaction with its paralog STAG1. Mechanistically, STAG1 loss abrogates sister chromatid cohesion in STAG2 mutated but not in wild-type cells leading to mitotic catastrophe, defective cell division and apoptosis. PMID: 28691904
    3. This first series reporting the phenotype ascribed to mutation in STAG1 highlights the importance of data sharing in the field of rare disorders. PMID: 28119487
    4. Data indicate that cohesin subunit SA-1 (STAG1) is a promising therapeutic target in cancers with inactivating alterations of cohesin subunit SA-2 (STAG2). PMID: 28430577
    5. There is LOH at STAG1 and STAG2 loci in oral squamous cell carcinoma (OSCC), but OSCC and NM showed similar transcriptional levels of STAG1, STAG2, and PDS5B. PMID: 27341316
    6. Data support the hypothesis that CTCF and cohesin SA-1 have multiple roles in the regulation of gene expression during erythropoiesis. PMID: 27219007
    7. TRF1 tethers SA1 within telomeric regions that SA1 transiently interacts with. SA1 and TRF1 together form longer DNA-DNA pairing tracts than with TRF1 alone, as revealed by atomic force microscopy imaging PMID: 27298259
    8. Nuclear import and export signals of human cohesins SA1/STAG1 and SA2/STAG2 expressed in Saccharomyces cerevisiae. PMID: 22715410
    9. Mutations in STAG1 is associated with acute myeloid leukemia. PMID: 24335498
    10. cohesin-SA1 and cohesin-SA2 participate in the DNA damage response PMID: 24324008
    11. Rad21 binds to SA proteins through two SA-binding motifs on Rad21. PMID: 23874961
    12. STAG1, a novel transcriptional target for p53, mediates p53-dependent apoptosis, and might be a good candidate for next-generation gene therapy in cancer. PMID: 15361841
    13. STAG1 (Scc3/SA1) subunit of cohesin interacts with the CCTC-binding factor CTCF bound to the c-myc insulator element. PMID: 18550811
    14. cohesin(SA1) and cohesin(SA2) are differentially required for telomere and centromere cohesion, respectively. PMID: 19822671

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  • 相关疾病：
    Mental retardation, autosomal dominant 47 (MRD47)
  • 亚细胞定位：
    Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.
  • 蛋白家族：
    SCC3 family
  • 数据库链接：

    HGNC: 11354

    OMIM: 604358

    KEGG: hsa:10274

    STRING: 9606.ENSP00000372689

    UniGene: Hs.412586