ST8SIA4 Antibody
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货号:CSB-PA821630ESR2HU
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规格:¥440
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促销:
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图片:
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其他:
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) ST8SIA4 Polyclonal antibody
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Uniprot No.:Q92187
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基因名:ST8SIA4
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别名:ST8SIA4 antibody; PST antibody; PST1 antibody; SIAT8D antibody; CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase antibody; EC 2.4.99.- antibody; Alpha-2,8-sialyltransferase 8D antibody; Polysialyltransferase-1 antibody; Sialyltransferase 8D antibody; SIAT8-D antibody; Sialyltransferase St8Sia IV antibody; ST8SiaIV antibody
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宿主:Rabbit
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反应种属:Human
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免疫原:Recombinant Human CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase protein (20-168AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:Antigen Affinity Purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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产品提供形式:Liquid
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应用范围:ELISA, IHC
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推荐稀释比:
Application Recommended Dilution IHC 1:20-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells.
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基因功能参考文献:
- Different properties of polysialic acids synthesized by the polysialyltransferases ST8SIA2 and ST8SIA4 have been described. PMID: 28810663
- our results demonstrate that miR-146a and miR-146b promote proliferation, migration and invasion of FTC via inhibition of ST8SIA4. PMID: 28427206
- Data show that miR-181c was inversely correlated with the levels of ST8SIA4 expression in chronic myelocytic leukemia (CML) cell lines and samples. PMID: 27527856
- This is the first report to demonstrate a role for a glycosyltransferase in human pluripotent stem cell lineage specification. PMID: 27074314
- changes in the glycosylation patterns and sialylation levels may be useful markers of the progression of breast cancer, as well as miR-26a/26b may be widely involved in the regulation of sialylation machinery by targeting ST8SIA4. PMID: 28032858
- The polybasic region of the polysialyltransferase ST8Sia-IV binds directly to NCAM. PMID: 28233978
- Sequence Requirements for Neuropilin-2 Recognition by ST8SiaIV and Polysialylation of Its O-Glycans. PMID: 26884342
- ST8SIA4 gene is involved in the development of multidrug resistance via PI3K/Akt pathway in chronic myeloid leukemia. PMID: 25855199
- this study indicated that sialylation involved in the development of MDR of AML cells probably through ST3GAL5 or ST8SIA4 regulating the activity of PI3K/Akt signaling and the expression of P-gp and MRP1. PMID: 24531716
- ST8SiaIV synthesized polySia selectively on a NRP2 glycoform that was characterized by the presence of sialylated core 1 and core 2 O-glycans. PMID: 23801331
- The ST8SiaIV/PST polybasic region plays a critical role in substrate recognition. PMID: 22184126
- polysialylated NCAM persistence, up-regulated polysialyltransferase-1 mRNA and previously uncovered defective myelin-associated glycoprotein may be early pathogenetic events in adult-onset autosomal-dominant leukodystrophy PMID: 19725832
- SIAT8D has a role in neural development and sialic acid synthesis on NCAM PMID: 12138100
- Pancreatitis risk was highest in individuals with abnormalities in pancreatic duct(CFTR) and acini (PST1) indicating that PST1 is a modifier gene for CFTR-related idiopathic chronic pancreatitis. PMID: 12227654
- The upregulation of ST8SIA4 and the donwregulation of ST8SIA2 by valproic acid in HUVEC and tumor cell lines are reported. PMID: 15710344
- polysialyltransferase ST8Sia IV/PST recognizes specific amino acids in the first fibronectin type III repeat of the neural cell adhesion molecule PMID: 16027151
- PSA-NCAM and ST8Sia-II/IV Expression Is Increased in Pancreatic Carcinomas PMID: 18384787
- Amino acid substitutions in conserved sequences are critical for the protein-specific polysialylation of NCAM. PMID: 19336400
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亚细胞定位:Golgi apparatus membrane; Single-pass type II membrane protein.
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蛋白家族:Glycosyltransferase 29 family
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组织特异性:Highly expressed in fetal brain, lung and kidney and in adult heart, spleen and thymus. Present to a lesser extent in adult brain, placenta, lung, large and small intestine and peripheral blood leukocytes.
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数据库链接:
HGNC: 10871
OMIM: 602547
KEGG: hsa:7903
STRING: 9606.ENSP00000231461
UniGene: Hs.308628
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