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ST8SIA2 Antibody

  • 货号：
    CSB-PA852840ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Alpha-2, 8-sialyltransferase 8B antibody at 8μg/ml
      Lane 1: Mouse heart tissue
      Lane 2: HepG2 whole cell lysate
      Lane 3: Mouse kidney tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 42 kDa
      Observed band size: 42 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA852840ESR2HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA852840ESR2HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ST8SIA2 Polyclonal antibody
  • Uniprot No.：
    Q92186
  • 基因名：
    ST8SIA2
  • 别名：
    ST8SIA2 antibody; SIAT8B antibody; STX antibody; Alpha-2,8-sialyltransferase 8B antibody; EC 2.4.99.- antibody; Sialyltransferase 8B antibody; SIAT8-B antibody; Sialyltransferase St8Sia II antibody; ST8SiaII antibody; Sialyltransferase X antibody; STX antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Alpha-2,8-sialyltransferase 8B protein (24-160AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression.
  • 基因功能参考文献：
    1. The ST8SIA2 risk haplotype copy number did not show any differential effects on white matter in schizophrenia. PMID: 29353880
    2. impairment of the regulated expression of ST8SIA2 and the resulting downstream effects on gene products by these two intronic single nucleotide polymorphism contribute to the development of these psychiatric disorders. PMID: 27565727
    3. ST8SiaII role in the invasiveness and metastasis of small cell lung cancer cells PMID: 28004110
    4. the relationships between psychiatric disorders and polySia and/or ST8SIA2 PMID: 27105834
    5. Data indicate a possible role of STX polysialyltransferase (ST8SIA2) in the common susceptibility of schizophrenia and bipolar I disorder (BD-I). PMID: 26418860
    6. Our study showed interesting sex-specific associations between ST8SIAII and schizophrenia. PMID: 24070986
    7. the role of ST8SIA2 sequence variation affecting polysialic acid-NCAM formation in 48 Caucasian cases with bipolar disorder PMID: 24651862
    8. translational modification of the neural cell adhesion molecule NCAM and the polysialyltransferase ST8SiaII in mammalian semen involves polysialic acid PMID: 23671285
    9. Expression of ST8SIA2 in omental fat at baseline was significantly associated with weight loss after Roux-en-Y gastric bypass. PMID: 23643386
    10. that variation the ST8SIA2 gene is associated with increased risk to mental illness PMID: 22693595
    11. NCAM and polySia are expressed and developmentally regulated in chick corneas. Both membrane-associated and soluble NCAM isoforms are expressed in chick corneas. PMID: 22281821
    12. ST8SIA2 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
    13. STX(G421A) shows a dramatic decrease in polySia synthetic activity on NCAM, whereas STX(C621G) does not; polySia shows a dopamine (DA) binding activity PMID: 21464126
    14. This study provided that ST8SIA2 are associated with Bipolar I in the Han Chinese population. PMID: 20386566
    15. SIAT8B has a role in neural development and sialic acid synthesis on NCAM PMID: 12138100
    16. SIAT8B gene is involved in schizophrenia in the Japanese. PMID: 16229822

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  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 29 family
  • 组织特异性：
    Highly expressed in fetal brain, kidney and heart and to a much lesser extent in adult heart and thymus.
  • 数据库链接：

    HGNC: 10870

    OMIM: 602546

    KEGG: hsa:8128

    STRING: 9606.ENSP00000268164

    UniGene: Hs.302341