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SSC1 Antibody

  • 货号：
    CSB-PA206965XA01SVG
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in Recombinant protein
      All lanes: SSC1 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 35.4 kDa
      Observed band size: 40 kDa
  • 其他：

产品详情

  • Uniprot No.：
    P0CS90
  • 基因名：
    SSC1
  • 别名：
    Heat shock protein SSC1, mitochondrial (Endonuclease SceI 75 kDa subunit) (Endo.SceI 75 kDa subunit) (mtHSP70) SSC1 ENS1 YJR045C J1639
  • 反应种属：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 免疫原：
    Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SSC1 protein (363-654aa)
  • 免疫原种属：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Protein G
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Constitutes the ATP-driven core of the motor and binds the precursor preprotein. Required for the import of the processed frataxin homolog YFH1 into the mitochondrion.
  • 基因功能参考文献：
    1. Amino acid substitution within SSC1 reveals structural elements within mtHsp70s that are required for allosteric modulation of the chaperone cycle. PMID: 24829379
    2. Results show that mtHsp70-Cox4 complex likely serves as a novel delivery system to channel Cox4 into the assembly line when needed. PMID: 23864706
    3. The intrinsic dynamics of the substrate-binding domain of Ssc1 was observed to be uncoupled from the dynamic interactions between substrate- and nucleotide-binding domains. PMID: 23624933
    4. the critical amino acid sequence of Ssc1 and Ssc3 that can "make or break" mtHsp70 chaperone function. PMID: 21474445
    5. interactions between Tim44 and mtHsp70, controlled by polypeptide binding, are required for efficient translocation across the mitochondrial inner membrane PMID: 15489862
    6. The N-terminal 167-amino-acid segment of mature Tim44 is sufficient for both interaction with mtHsp70 and destabilization of a Tim44-mtHsp70 complex caused by client protein binding. PMID: 18426906

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  • 亚细胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Heat shock protein 70 family
  • 数据库链接：

    KEGG: sce:YJR045C

    STRING: 4932.YJR045C