Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. SS18L1 Antibody

SS18L1 Antibody

  • 货号：
    CSB-PA022701GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O75177
  • 基因名：
    SS18L1
  • 别名：
    Calcium-responsive transactivator antibody; CREST antibody; CREST_HUMAN antibody; KIAA0693 antibody; LP2261 antibody; MGC26711 antibody; MGC78386 antibody; sarcoma translocation gene on chromosome18like1 antibody; SS18 antibody; SS18-like protein 1 antibody; SS18L1 antibody; SS18L1 nBAF chromatin remodeling complex antibody; SSXT antibody; synovial sarcoma translocation antibody; synovial sarcoma translocation gene on chromosome 18-like 1 antibody; SYT homolog 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CREST
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP.
  • 基因功能参考文献：
    1. calcium-responsive transactivator and certain other amyotrophic lateral sclerosis-linked proteins share several features implicated in amyotrophic lateral sclerosis pathogenesis PMID: 25888396
    2. Its mutation causes amyotrophic lateral sclerosis. PMID: 24360741
    3. This study demonistrated that CREST mutations inhibited activity-dependent neurite outgrowth in primary neurons, and CREST associated with the ALS protein FUS. PMID: 23708140
    4. A synovial sarcoma of classic morphology contained a novel t(20;X) SS18L1(strong homology to SS18 on Ch20)/SSX1 fusion transcript in which nucleotide 1216 (exon 10) of SS18L1 was fused in-frame with nucleotide 422 (exon 6) of SSX1. PMID: 12696068
    5. analysis of the CREST domain that inhibits dendritic growth in cultured neurons PMID: 15866867
    6. SS18 and SS18L1 genes map within co-linear DNA segments that may have evolved through a relatively recent genomic duplication event. PMID: 16484776

    显示更多

    收起更多

  • 亚细胞定位：
    Nucleus. Chromosome, centromere, kinetochore.
  • 蛋白家族：
    SS18 family
  • 组织特异性：
    Ubiquitous; with lowest levels in spleen.
  • 数据库链接：

    HGNC: 15592

    OMIM: 606472

    KEGG: hsa:26039

    STRING: 9606.ENSP00000333012

    UniGene: Hs.154429