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SRSF7 Antibody

  • 货号：
    CSB-PA000772
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HuvEc cells using 9G8 Polyclonal Antibody
    • Western Blot analysis of HuvEc cells using 9G8 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q16629
  • 基因名：
    SRSF7
  • 别名：
    9G8 antibody; AAG3 antibody; arginine/serine-rich 7 antibody; HSSG1 antibody; RBM37 antibody; Serine/arginine-rich splicing factor 7 antibody; Splicing factor 9G8 antibody; Splicing factor antibody; Splicing factor, arginine/serine rich 7 antibody; SRSF7 antibody; SRSF7_HUMAN antibody; ZCCHC20 antibody; ZCRB2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human 9G8.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.
  • 基因功能参考文献：
    1. role of SRSF7 in cell proliferation through regulating p21 levels. PMID: 27644562
    2. SRSF7 expression in cancer cells is regulated by microRNAs: short, non-coding RNAs that bind to 3'UTR of target genes and downregulate their expression. SRSF7 regulate proliferation of renal cancer cells.SRSF7 regulates expression of osteopontin. PMID: 27664584
    3. Genome-wide identification of CD95 antigen alternative splicing regulators, such as SRSF7, reveals links with iron homeostasis. PMID: 25482508
    4. Coexpression of Dyrk1A and splicing factor 9G8 leads to their translocation from the nucleus to the cytoplasm and suppresses their ability to regulate tau exon 10 splicing. PMID: 21215488
    5. Cyclic AMP-dependent protein kinase regulates 9G8-mediated alternative splicing of tau exon 10 PMID: 22677170
    6. Upregulation of total tau expression (SFRS7-independent) and tau exon 10 splicing (SFRS7-dependent), as shown in this study to be both affected by STOX1A, is known to have implications in neurodegeneration. PMID: 21755018
    7. These results indicate that 9G8 plays a key role in regulation of exon 10 splicing and imply a pathogenic role in neurodegenerative diseases. PMID: 17137791
    8. 9G8 was shown to enhance expression of unspliced RNA containing either the Mason-Pfizer monkey virus constitutive transport element PMID: 17513303
    9. eIF3f mediates restriction of HIV-1 expression through a set of factors that includes eIF3f, the SR protein 9G8, and the cyclin-dependent kinase 11 (CDK11). PMID: 19854136

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Splicing factor SR family
  • 组织特异性：
    Brain, liver, kidney and lung.
  • 数据库链接：

    HGNC: 10789

    OMIM: 600572

    KEGG: hsa:6432

    STRING: 9606.ENSP00000325905

    UniGene: Hs.309090