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SRRT Antibody

  • 货号：
    CSB-PA880129ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA880129ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA880129ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SRRT Polyclonal antibody
  • Uniprot No.：
    Q9BXP5
  • 基因名：
    SRRT
  • 别名：
    ARS2 protein antibody; Arsenate resistance protein ARS2 antibody; Arsenite resistance protein 2 antibody; Arsenite resistance protein antibody; Arsenite-resistance protein 2 antibody; ASR2 antibody; MGC126427 antibody; Serrate antibody; Serrate RNA effector molecule antibody; Serrate RNA effector molecule homolog (Arabidopsis) antibody; Serrate RNA effector molecule homolog antibody; SRRT antibody; SRRT_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Serrate RNA effector molecule homolog protein (627-876AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription.
  • 基因功能参考文献：
    1. Study present the human ARS2 crystal structure, which exhibits similarities and metazoan-specific differences to the plant homologue SERRATE, most notably an additional RRM domain. RRM domain is required to bind RNA, whereas a basic patch in the C-terminal leg of ARS2 mediates the interaction with FLASH. PMID: 29703953
    2. define two mutually exclusive complexes CBC-NELF-E and CBC-ARS2-PHAX, which likely act in respectively earlier and later phases of transcription PMID: 29101316
    3. ARS2 depletion negatively impacts levels of promoter-proximal RNA polymerase II at protein-coding genes. It is involved in transcription termination events within first introns of pc genes. ARS2 plays a role in transcription termination-coupled RNA turnover at short transcription units like snRNA-, replication-dependent histone-, promoter upstream transcript- and enhancer RNA-loci. PMID: 28973446
    4. 2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-kappaB, AP-1 and MAPK pathways in human proximal tubular cells. PMID: 26404762
    5. Ars2 is overexpressed in HCC and may have prognostic value; it might play an important role in HCC proliferation and miR-21 expression. PMID: 24272391
    6. Ars2 contributes to histone mRNA 3' end formation and expression and these functional properties of Ars2 are negatively regulated by interaction with 7SK RNA. PMID: 22244333
    7. These data indicate ARS2 is essential for early mammalian development and is likely involved in an essential cellular process. PMID: 18086880
    8. These findings provide evidence for a role for Ars2 in RNA interference regulation during cell proliferation. PMID: 19632182
    9. Validated occurrence of an unusual TG 3' splice site in intron 17 (NM_015908). PMID: 17672918
    10. Nomenclature. Original paper and GenBank submission by Rossman and Wang (1999) called the gene Asr2 (arsenite resistance protein 2) as opposed to Ars2 (arsenate resistance protein 2). PMID: 10069470

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  • 亚细胞定位：
    Nucleus, nucleoplasm. Cytoplasm.
  • 蛋白家族：
    ARS2 family
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 24101

    OMIM: 614469

    KEGG: hsa:51593

    STRING: 9606.ENSP00000314491

    UniGene: Hs.111801