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SRRM2 Antibody

  • 货号：
    CSB-PA892369LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA892369LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SRRM2 Polyclonal antibody
  • Uniprot No.：
    Q9UQ35
  • 基因名：
    SRRM2
  • 别名：
    300 kDa nuclear matrix antigen antibody; CWC21 antibody; KIAA0324 antibody; Ser/Arg-related nuclear matrix protein of 300 kDa antibody; Serine/arginine repetitive matrix protein 2 antibody; Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa antibody; Splicing coactivator subunit SRm300 antibody; SR-related nuclear matrix protein of 300 kDa antibody; SRL300 antibody; SRM300 antibody; SRRM2 antibody; SRRM2_HUMAN antibody; Tax-responsive enhancer element-binding protein 803 antibody; TaxREB803 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Serine/arginine repetitive matrix protein 2 protein (248-462AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SRRM2 Antibody (CSB-PA892369LA01HU)，的标记方式是Non-conjugated。对于SRRM2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA892369LB01HU SRRM2 Antibody, HRP conjugated ELISA
    FITC CSB-PA892369LC01HU SRRM2 Antibody, FITC conjugated
    Biotin CSB-PA892369LD01HU SRRM2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for pre-mRNA splicing as component of the spliceosome.
  • 基因功能参考文献：
    1. cellular complexes comprising cactin, DHX8 and SRRM2 sustain precise chromosome segregation, genome stability and cell proliferation by allowing faithful splicing of specific pre-mRNAs. PMID: 28062851
    2. The S346F mutation in SRRM2 predisposes to papillary thyroid carcinoma by affecting alternative splicing of unidentified downstream target genes. PMID: 26135620
    3. Data show that the consistent dysregulation of the RNA splicing factor SRRM2 in two different PD neuronal sources and in PD blood makes SRRM2 a strong candidate gene for PD and draws attention to the role of RNA splicing in the disease. PMID: 20161708
    4. results suggest multiple functions for Cwc21/SRm300 in the splicing process, including an important role in the activation of splicing in association with Isy1. PMID: 19789211
    5. demonstrate that SRm300, the only serine arginine-related protein known to be at the core of human catalytic spliceosomes, is a functional ortholog of Cwc21p, also interacting directly with Prp8p and Snu114p. PMID: 19854871

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  • 亚细胞定位：
    Nucleus. Nucleus speckle.
  • 蛋白家族：
    CWC21 family
  • 组织特异性：
    Expressed in liver, placenta, and white blood cells.
  • 数据库链接：

    HGNC: 16639

    OMIM: 606032

    KEGG: hsa:23524

    STRING: 9606.ENSP00000301740

    UniGene: Hs.433343