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SRP68 Antibody

  • 货号：
    CSB-PA962918
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA962918(SRP68 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9UHB9
  • 基因名：
    SRP68
  • 别名：
    Signal recognition particle 68 antibody; Signal recognition particle 68 kDa antibody; Signal recognition particle 68 kDa protein antibody; signal recognition particle 68kD antibody; Signal recognition particle 68kDa antibody; signal recognition particle subunit SRP68 antibody; SRP 68 antibody; SRP68 antibody; SRP68_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human SRP68
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.
  • 基因功能参考文献：
    1. The essential role of the SRP68-SRP72 interaction in the signal recognition particle-mediated protein translocation PMID: 28369529
    2. study presents the crystal structures of the RNA-binding domain of SRP68 (SRP68-RBD) alone and in complex with SRP RNA and SRP19; data provide the structural basis for eukaryote-specific, SRP68-driven RNA remodeling required for protein translocation PMID: 24700861
    3. SRP68/72 heterodimers as major nuclear proteins whose binding of histone H4 tail is inhibited by H4R3 methylation. PMID: 23048028
    4. The RNA binding domain of SRP68 included residues from positions 52 to 252. Ninety-four amino acids near the C terminus of SRP68 mediated the binding to SRP72 PMID: 16672232
  • 亚细胞定位：
    Cytoplasm. Nucleus, nucleolus.
  • 蛋白家族：
    SRP68 family
  • 数据库链接：

    HGNC: 11302

    OMIM: 604858

    KEGG: hsa:6730

    STRING: 9606.ENSP00000312066

    UniGene: Hs.514495