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SRFBP1 Antibody

  • 货号：
    CSB-PA022660GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8NEF9
  • 基因名：
    SRFBP1
  • 别名：
    p49 / STRAP antibody; p49 antibody; p49/STRAP antibody; serum response factor binding protein 1 antibody; Serum response factor-binding protein 1 antibody; SRF dependent transcription regulation associated protein antibody; SRF-dependent transcription regulation-associated protein antibody; SRFB1_HUMAN antibody; SRFBP 1 antibody; SRFBP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human SRFBP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.
  • 基因功能参考文献：
    1. P49/STRAP expression was increased in the old versus young adult mouse hearts and also increased with advancing population doubling levels in cultured human umbilical vein endothelial cells. The increased expression of p49/STRAP in late life may alter the status of histone acetylation and impact mitochondrial dynamics and thereby reduce mitochondrial function and cardiac performance during mammalian senescence. PMID: 27337995
    2. SRFBP1 is an HCV-specific, pan-genotypic host entry factor. PMID: 26212323
    3. p49/STRAP may be an important SRF cofactor in the transcriptional regulation of mammalian cardiac muscle genes throughout the life span PMID: 15492011
    4. p49/STRAP plays a role in the regulation of intracellular processes such as cardiac cellular metabolism, gene expression, and possibly aging. PMID: 18230186
    5. p49/STRAP can be considered a bona fide co-chaperone of Hsp70. PMID: 19751705

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  • 亚细胞定位：
    Cytoplasm, perinuclear region.
  • 组织特异性：
    Abundantly expressed in heart and skeletal muscle, and at much lower levels in brain and lung.
  • 数据库链接：

    HGNC: 26333

    OMIM: 610479

    KEGG: hsa:153443

    STRING: 9606.ENSP00000341324

    UniGene: Hs.107622