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SRCIN1 Antibody

  • 货号：
    CSB-PA003616
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HepG2 cells using p140Cap Polyclonal Antibody
    • Western Blot analysis of 293T HELA cells using p140Cap Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9C0H9
  • 基因名：
    SRCIN1
  • 别名：
    p130Cas associated protein antibody; p130Cas-associated protein antibody; P140 antibody; p140Cap antibody; SNAP-25-interacting protein antibody; SNIP antibody; SRC kinase signaling inhibitor 1 antibody; SRCIN1 antibody; SRCN1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human p140Cap.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.
  • 基因功能参考文献：
    1. SRCIN1 functions to inhibit the proliferation and EMT of human liver cancer HepG2 cells. PMID: 28550679
    2. Data indicate that the major mechanism is the ability of p140Cap to interfere with ERBB2-dependent activation of Rac GTPase-controlled circuitries. PMID: 28300085
    3. Study demonstrates a critical role of presynaptic cadherin/catenin/p140Cap cell adhesion complexes in stabilizing functional synapses and spines in the developing neocortex. PMID: 28641114
    4. SRCIN1 underexpression is associated with Osteosarcoma. PMID: 27513473
    5. Together, these results demonstrate that Srcin1 contributes to CRC carcinogenesis, invasion and metastasis. These findings provide a rationale for a mechanistic approach to CRC treatment based on the development of Srcin1-targeted therapies PMID: 28393242
    6. miR-211 may function as an oncogenic miRNA in non-small cell lung cancer, partly by regulating SRCIN1 PMID: 26277787
    7. miR-346 may function as an oncogenic miRNA and mediate chemosensitivity to docetaxel through targeting SRCIN1 in breast cancer PMID: 27913185
    8. these results reveal a novel function of postsynaptic endophilin A1 in spine morphogenesis, stabilization and synaptic function through the regulation of p140Cap PMID: 25771685
    9. these findings suggest that miR-374a functions as a candidate oncogene in GC by directly targeting SRCIN1 PMID: 25554419
    10. Findings indicate the role of miR-150 as an oncogene in lung cancer through the inhibition of SRC kinase signalling inhibitor 1 (SRCIN1) translation. PMID: 24456795
    11. p140Cap phosphorylation sites and binding to Csk and Abl kinase PMID: 23383002
    12. p140Cap immobilizes E-cadherin at the cell membrane and inhibits EGFR and Erk1/2 signalling, blocking scatter and proliferation of cancer cells. PMID: 20453886
    13. provides the first evidence that p140Cap is a novel negative regulator of tumour growth PMID: 17525734
    14. Expression correlated significantly with unfavourable overall survival, suggesting that SNIP/p140Cap may be a useful diagnostic and prognostic marker, aas well as therapeutic target, in breast cancer. PMID: 18475297

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse, presynapse. Cell junction, synapse, postsynapse. Cell junction, synapse, postsynaptic density.
  • 蛋白家族：
    SRCIN1 family
  • 组织特异性：
    Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue.
  • 数据库链接：

    HGNC: 29506

    OMIM: 610786

    KEGG: hsa:80725

    STRING: 9606.ENSP00000264659

    UniGene: Hs.448872