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SPRR1A Antibody

  • 货号：
    CSB-PA022610LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA022610LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA022610LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA022610LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SPRR1A Polyclonal antibody
  • Uniprot No.：
    P35321
  • 基因名：
    SPRR1A
  • 别名：
    SPRR1A antibody; Cornifin-A antibody; 19 kDa pancornulin antibody; SPRK antibody; Small proline-rich protein IA antibody; SPR-IA antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Cornifin-A protein (8-72AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SPRR1A Antibody (CSB-PA022610LA01HU)，的标记方式是Non-conjugated。对于SPRR1A Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA022610LB01HU SPRR1A Antibody, HRP conjugated ELISA
    FITC CSB-PA022610LC01HU SPRR1A Antibody, FITC conjugated
    Biotin CSB-PA022610LD01HU SPRR1A Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
  • 基因功能参考文献：
    1. mRNA levels of LELP1, SPRR1Av1, and SPRR1Av2 were significantly higher in the skin of patients with AD compared with the control group. PMID: 27304082
    2. the SPRR1A status might play an important role in the prognosis of postmenopausal breast carcinoma patients, especially that of progesterone receptor-positive subgroups. PMID: 25424702
    3. A expression may be useful as a prognostic factor for diffuse large B-cell lymphoma. PMID: 24886019
    4. Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families. PMID: 18643845
    5. the deregulated increase in SPRR1A expression in chronic atopic skin lesions reflects an insufficient rise in SPRR transcripts, unable to compensate for the lack of LOR and thus contributing to the persistence of chronic atopic dermatitis skin lesions. PMID: 19672094

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Cornifin (SPRR) family
  • 数据库链接：

    HGNC: 11259

    OMIM: 182265

    KEGG: hsa:6698

    STRING: 9606.ENSP00000307340

    UniGene: Hs.46320