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SPRED2 Antibody

  • 货号：
    CSB-PA800221DSR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA800221DSR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SPRED2 Polyclonal antibody
  • Uniprot No.：
    Q7Z698
  • 基因名：
    SPRED2
  • 别名：
    SPRED2 antibody; Sprouty-related antibody; EVH1 domain-containing protein 2 antibody; Spred-2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Sprouty-related, EVH1 domain-containing protein 2 protein (120-300AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Negatively regulates Ras signaling pathways and downstream activation of MAP kinases. Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells.
  • 基因功能参考文献：
    1. Our findings show that miR-487a, mediated by heat shock factor 1, promotes proliferation and metastasis of Hepatocellular carcinoma (HCC) by PIK3R1 and SPRED2 binding, respectively. Our study provides a rationale for developing miR-487a as a potential prognostic marker or a potential therapeutic target against HCC. PMID: 27827315
    2. data indicate that Spred2 induces tumor cell death in an autophagy-dependent manner. PMID: 27028858
    3. Spred2 was involved in erythroid differentiation of chronic myeloid leukemia cells and participated in imatinib induced erythroid differentiation partly through ERK signaling. PMID: 25688862
    4. Downregulation of SPRED2 mRNA is associated with prostate cancer. PMID: 23169297
    5. Data present that galectin-1, ataxin-3 and sprouty-related EVH1 domain-containing protein 2 (SPRED2) may be associated with the progression and development of Down syndrome. PMID: 22777171
    6. Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with the p85 subunit of phosphatidylinositol 3-kinase. PMID: 22305891
    7. the knockdown of Spred2 markedly enhanced tumor growth in vivo. PMID: 21703232
    8. data in the present study suggests that Spred2 is a regulator of TGF-beta1-induced malignance in transformed keratinocytes PMID: 19908229
    9. NMR assignment of the human Spred2 EVH1 domain PMID: 15213456
    10. Spred-2 was found to be strongly expressed in glandular epithelia and, at the subcellular level, its immunoreactivity was associated with secretory vesicles. It becomes most likely that Spred-2 is involved in the regulation of secretory pathways PMID: 15580519
    11. Loss of Spred-2 inhibits bone growth in transgenic mice by inhibiting chondrocyte differentiation through up-regulation of the MAPK signaling pathway. PMID: 15946934
    12. These results suggest a role for Spred-2 tyrosine phosphorylation and ubiquitination in controlling Spred-2 expression levels. PMID: 17094949
    13. Linkage analysis of SPRED2 excluded its involvement in Cafe-au-lait spots in a patient with a severe form of Noonan syndrome. PMID: 19120036
    14. findings suggest a critical function for NBR1 in the regulation of receptor trafficking and provide a mechanism for down-regulation of signaling by Spred2 via NBR1. PMID: 19822672

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
  • 组织特异性：
    Expressed in liver, skin, small intestine, salivary gland and prostate.
  • 数据库链接：

    HGNC: 17722

    OMIM: 609292

    KEGG: hsa:200734

    STRING: 9606.ENSP00000348753

    UniGene: Hs.59332