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SPOCK1 Antibody

  • 货号：
    CSB-PA730785LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA730785LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA730785LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: Mouse brain tissue
      All lanes: SPOCK1 antibody at 1:3000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 50 kDa
      Observed band size: 50 kDa
    • Western Blot
      Positive WB detected in: 293T whole cell lysate
      All lanes: SPOCK1 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 50 kDa
      Observed band size: 50 kDa
  • 其他：

产品详情

  • 产品描述：

    The SPOCK1 polyclonal antibody CSB-PA730785LA01HU was produced in the rabbit immunized with the recombinant human Testican-1 protein (290-435aa). The target protein SPOCK1, also known as Testican-1 protein, mainly modulates cell adhesion, migration, and proliferation by interacting with other ECM proteins, proteases, and growth factors.

    This SPOCK1 antibody was tested in the ELISA, WB, IHC, and IF applications. The non-conjugated IgG got purified by protein G affinity chromatography and reached up to 95% in purity. It reacts with the SPOCK1 proteins from human and mouse samples.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SPOCK1 Polyclonal antibody
  • Uniprot No.：
    Q08629
  • 基因名：
    SPOCK1
  • 别名：
    SPOCK1 antibody; SPOCK antibody; TIC1 antibody; TICN1 antibody; Testican-1 antibody; Protein SPOCK antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Testican-1 protein (290-435AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SPOCK1 Antibody (CSB-PA730785LA01HU)，的标记方式是Non-conjugated。对于SPOCK1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA730785LB01HU SPOCK1 Antibody, HRP conjugated ELISA
    FITC CSB-PA730785LC01HU SPOCK1 Antibody, FITC conjugated
    Biotin CSB-PA730785LD01HU SPOCK1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:2000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.
  • 基因功能参考文献：
    1. Testican-1 blood level is related to the severity of sepsis and Testican-1 could be used as a biomarker to determine the severity of sepsis. PMID: 29315764
    2. Overexpression of SPOCK1was confirmed in head and neck squamous cell carcinoma clinical specimens. Overexpression of SPOCK1 contributes to the aggressive nature of HNSCC. PMID: 29233721
    3. High SPOCK1 expression is associated with castration-resistant prostate cancer. PMID: 28534948
    4. downregulation of both strands of pre-miR-150 and overexpression of SPOCK1 are involved in esophageal squamous cell carcinoma (ESCC). pathogenesis. The involvement of passenger strand miRNAs in the regulation of cancer cell aggressiveness is a novel concept in RNA research PMID: 28659612
    5. is significantly upregulated in osteosarcoma tissue. PMID: 28869894
    6. Functional assessment in cocultures demonstrated that SPOCK1 strongly affects the composition of the extracellular collagen matrix and by doing so, enables invasive tumor cell growth in Pancreatic ductal adenocarcinoma. PMID: 28486750
    7. Transcriptomic analysis of EPCR-silenced tumors unveiled an effect mediated by matricellular SPOCK1/testican 1. SPOCK1 silencing suppressed in vitro 3D growth. SPOCK1 ablation decreased orthotopic tumor growth and reduced metastatic osteolytic tumors. High SPOCK1 levels were also associated with poor clinical outcome in a subset of breast cancer patients. PMID: 28103946
    8. a novel TGF-beta-induced myoepithelial marker and enhanced invasion in breast cancer cells and correlated with poor prognosis PMID: 27626636
    9. Our results suggested that microRNA-129-5p could directly specifically suppress SPOCK1, which might be one of the potential mechanisms in inhibiting cell processes including viability, proliferation, cell mitosis, migration, and invasiveness of gastric cancer cells. PMID: 28653880
    10. SPOCK1 expression is significantly up-regulated in colorectal cancer tissues and associated with tumor size and stage. SPOCK1 stimulates the PI3K/AKT signaling pathway to inhibit cell apoptosis and promote tumor growth. PMID: 27889608
    11. findings suggest that SPOCK1 is a critical mediator of tumor growth and metastasis in prostate cancer PMID: 27486308
    12. Knockdown of SPOCK1 inhibits the proliferation. PMID: 28281964
    13. This study suggests that SPOCK1 promotes proliferation, migration and invasion in glioma cells by activating PI3K/AKT and Wnt/beta-catenin pathways, which provides a potential theoretical basis for clinical treatment of glioma. PMID: 27108836
    14. SPOCK1 is highly expressed in ovarian cancer.SPOCK1 contributes to ovarian cancer development and metastasis. PMID: 26638890
    15. These results suggest that up-regulation of SPOCK1 in ESCC induces EMT, thus promotes migration and invasion in ESCC cells. PMID: 26077618
    16. Collectively, altered expression of PKP1 and SPOCK1 appears to be a frequent and critical event in prostate cancer PMID: 26138584
    17. SPOCK1 activates PI3K/Akt signaling. PMID: 25623055
    18. Testican-1-induced EMT signaling. PMID: 23873022
    19. this study showed that SPOCK1 is a novel metastasis related biomarker in lung cancer and may be new diagnostic and therapeutic target for lung cancer. PMID: 24134845
    20. In the present study, we showed that SPOCK1 could inhibit apoptosis and promote cancer invasion. PMID: 23022495
    21. Significant overexpression of osteonectin mRNA is associated with pancreatic cancer PMID: 16596217
    22. SPOCK gene underlies variation of age at menarche PMID: 19282985

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 数据库链接：

    HGNC: 11251

    OMIM: 602264

    KEGG: hsa:6695

    STRING: 9606.ENSP00000282223

    UniGene: Hs.596136