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SP2 Antibody

  • 货号：
    CSB-PA050125
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q02086
  • 基因名：
    SP2
  • 别名：
    Kiaa0048 antibody; OTTHUMP00000196580 antibody; SP2 antibody; SP2_HUMAN antibody; SPECIFICITY PROTEIN 2 antibody; Transcription factor Sp2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human Sp2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.
  • 基因功能参考文献：
    1. This study presented that a Novel Mutation (Gly212Val) in the PS2 Gene Associated with Early-Onset Familial Alzheimer's Disease. PMID: 27128372
    2. SP2 recognized binding motifs in the human RORgammaT promoter, which was critical for maintaining expression. SP2 was necessary for maximum IL-17 expression in in vitro-differentiated Th17 cells. SP 2 plays a role in Th17-dependent physiologic and pathologic immune responses. PMID: 27256574
    3. O-GlcNAc modification of Sp3 and Sp4, but not Sp2 transcription factors negatively regulates their transcriptional activities. PMID: 26431879
    4. Sp2 is up-regulated in gastric cancer tissues PMID: 24623314
    5. Data show that three Sp1 motifs located between -148 and -42bp upstream of the first exon were important in basic as well as in DA-induced NSMase2 promoter activity. PMID: 19698806
    6. an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration PMID: 17071613
    7. Despite the absence of Sp2 in the 5'-upstream sequence of the human promoter, silencing of Sp2 by RNA interference clearly demonstrated that Sp2 is required for IFN-gamma-induced regulation of socs1 mRNA both in human and mouse. PMID: 19482358

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Sp1 C2H2-type zinc-finger protein family
  • 数据库链接：

    HGNC: 11207

    OMIM: 601801

    KEGG: hsa:6668

    STRING: 9606.ENSP00000365931

    UniGene: Hs.514276