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SOX1 Antibody

  • 货号：
    CSB-PA440480
  • 规格：
    ￥1100
  • 图片：
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human liver cancer tissue, 293T cells, Primary antibody: CSB-PA440480(SOX1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他：

产品详情

  • Uniprot No.：
    O00570
  • 基因名：
  • 别名：
    Sex determining region Y box 1 antibody; sox1 antibody; SOX1_HUMAN antibody; SRY antibody; SRY box containing gene 1 antibody; SRY related HMG box gene 1 antibody; Transcription factor Sox-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human SOX1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    WB 1:200-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation.
  • 基因功能参考文献：
    1. SOX1 overlapping transcript was found to be highly expressed in differentiated neural stem cells across different time points of differentiation, and its expression correlated with SOX1 gene expression. PMID: 28674729
    2. The sensitivity was found to be 62% and 83% for DAPK1 and SOX1, respectively, when analyzed separately in the singleplex assay, but increased to 90% in the multiplex assay when either or both of the SOX1 and the DAPK1 gene promoters showed methylation. PMID: 27452040
    3. Taken together, these data suggest that SOX1 can function as a tumor suppressor partly by interfering with Wnt/beta-catenin signaling in breast cancer. PMID: 27206213
    4. the under-expression of SOX1 was associated significantly with SALL4 overexpression. This study was the first to evaluate SOX1 underexpression and its association with poor prognosis in esophageal squamous cell carcinoma. PMID: 27576349
    5. The results of the SRY gene amplification of plasma DNA from pregnant women was the same as that of the amniocyte DNA PMID: 26782455
    6. The analysis identified a signaling axis between FGF signaling and the transcription factor Sox1, which is preferentially expressed in stem- and mesenchymal-like breast cancers. PMID: 26365194
    7. downregulation of SOX-1 was correlated with poor prognosis and tumor development in hepatocellular carcinoma. PMID: 26191244
    8. SOX 1 suppressed cell growth and invasion in Tu212 cells by inhibiting Wnt pathway, and the anti-tumor effect of SOX 1 could be weakened by SOX 2, which may be a potential molecular basis for clinical treatment of laryngeal squamous cell carcinoma . PMID: 26040764
    9. Our results suggest that SOX1 is epigenetically silenced in the majority of NSCLC and restoration of SOX1 inhibited cell migration by regulating actin cytoskeletal remodeling in NSCLC. PMID: 25613070
    10. SOX1 decreases the expression of beta-catenin in a proteasome-independent manner. PMID: 25427424
    11. PAX1 and SOX1 DNA methylation correlate with a cervical intraepithelial neoplasia diagnosis. PMID: 24799352
    12. we successfully established a three-step inducing protocol to derive Neural stem cells from adipose-derived mesenchymal stem cells with high purity by Sox1 activation PMID: 24138016
    13. The methylation index of SOX1 recovered from scrapings of uterine cervix adenocarcinomas is significantly higher than in normal controls. PMID: 24407576
    14. Taken together, these data suggest that SOX1 can function as a tumor suppressor partly by interfering with Wnt/beta-catenin signaling in cervical cancer. PMID: 23927962
    15. Inactivation of SOX1 gene is associated with cisplatin resistance in human non-small cell lung cancer cell. PMID: 23994634
    16. Concomitant epigenetic silencing of SOX1 and SFRPs through promoter hypermethylation is frequent in hepatocellular carcinoma, and this might contribute to abnormal activation of canonical Wnt signal pathway. PMID: 23215838
    17. The level and timing of SOX1 expression affects neural induction as well as neural lineage. PMID: 22860217
    18. These findings suggest that SOX1 might function as an important tumor suppressor during the development of hepatocellular carcinoma. PMID: 22767186
    19. SOX1 antibodies are a specific marker for SCLC-LEMS but they are also found in SCLC patients without paraneoplastic neurological syndromes PMID: 23278580
    20. Transgenic interneuron diversification in the p2 domain is more complex than previously thought and directly implicates Sox1 in this process. PMID: 20844123
    21. Supratentorial PNETs expressed significantly higher levels of SOX2, NOTCH1, ID1, and ASCL-1 transcripts. PMID: 20515335
    22. Sox1 works through multiple independent pathways to promote neuronal cell fate determination and differentiation. PMID: 15110721
    23. The detection of SOX1 antibodies in patients with Lambert-Eaton myasthenic syndrome (LEMS) predicts the presence of small cell lung cancer and may be used to follow more closely those LEMS patients with no evidence of cancer at the initial workup. PMID: 18032743
    24. expression of Sox1, Sox2 and Sox9 was detected at the mRNA level in both foetal and adult cerebellum samples; Sox1, Sox2 and Sox9 expression was detected in the Purkinje cell layer of the adult cerebellum PMID: 19061938
    25. Data show that SOX antibodies have diagnostic value in discriminating SCLC-LEMS from nontumor LEMS, but have no relation to survival in patients with SCLC. PMID: 19667272
    26. A similar protein directly regulates the gamma-crystallin genes and is essential for lens development in mice. PMID: 9512512

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Mainly expressed in the developing central nervous system.
  • 数据库链接：

    HGNC: 11189

    OMIM: 602148

    KEGG: hsa:6656

    STRING: 9606.ENSP00000330218

    UniGene: Hs.202526