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SOS1 Antibody

  • 货号：
    CSB-PA726788LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Rat brain tissue
      All lanes: SOS1 antibody at 4.6μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 153, 37 kDa
      Observed band size: 153 kDa
    • IHC image of CSB-PA726788LA01HU diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA726788LA01HU diluted at 1:400 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of Hela cells with CSB-PA726788LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SOS1 Polyclonal antibody
  • Uniprot No.：
    Q07889
  • 基因名：
  • 别名：
    alternate SOS1 antibody; GF1 antibody; GGF1 antibody; GINGF antibody; gingival fibromatosis antibody; gingival fibromatosis hereditary 1 antibody; Guanine nucleotide exchange factor antibody; HGF antibody; NS4 antibody; Son of sevenless homolog 1 (Drosophila) antibody; Son of sevenless homolog 1 antibody; SOS Ras/Rac guanine nucleotide exchange factor 1 antibody; SOS-1 antibody; Sos1 antibody; SOS1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Son of sevenless homolog 1 protein (1140-1281AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SOS1 Antibody (CSB-PA726788LA01HU)，的标记方式是Non-conjugated。对于SOS1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA726788LB01HU SOS1 Antibody, HRP conjugated ELISA
    FITC CSB-PA726788LC01HU SOS1 Antibody, FITC conjugated
    Biotin CSB-PA726788LD01HU SOS1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity.
  • 基因功能参考文献：
    1. a distinct role of the C-terminal proline-rich (PR) domain of the full-length son of sevenless homolog 1 (SOS1) protein. PMID: 28452363
    2. SOS1 was statistically significantly associated with gestational diabetes mellitus risk after adjusting for multiple comparisons PMID: 29233017
    3. Findings identified p.Ser548Arg missense mutation in Son of Sevenless Homolog 1 (SOS1) in the boy, confirmed in his mother. PMID: 28456002
    4. We report on a novel pathogenic mutation in the SOS1 gene and a large clinical spectrum in a Noonan syndrome family with ten genetically confirmed affected individuals. PMID: 28884940
    5. Data indicate dynamic of H-Ras functional cycle as controlled by son of sevenless homolog 1 (Sos). PMID: 27412770
    6. In summary, patients from two families with history of non-syndromic autosomal-dominant HGF from Malopolska and Mazovia provinces in Poland had not been affected by HGF type 1, caused by a single-cytosine insertion in exon 21 of the SOS-1 gene. PMID: 28425619
    7. Mutation scanning of the entire coding sequence of SOS1 gene identified seven intronic variants and one new exonic substitution (c.138G > A). The seven common intronic variants were not considered to be of pathogenic importance. The exonic substitution c.138G > A was found to be absent in 100 ethnically matched normal control chromosomes, not expected to have functional significance based on prediction bioinformatics tool PMID: 28433619
    8. Grb2-independent interactions are sufficient to retain human SOS on the membrane for many minutes, during which a single SOS molecule could processively activate thousands of Ras molecules. PMID: 27501536
    9. a computational methodology that overlays any variant database onto the somatic mutations in all cancer exomes identified activating SOS1 mutations associated with Noonan syndrome as significantly altered in melanoma PMID: 27304678
    10. Data show that a heterozygous son of sevenless homolog 1 (SOS1) gene frameshift mutation (c.3266dup or c.3248dup) was identified in each patient. PMID: 26708403
    11. Ras.GDP weakly binds to the catalytic but not to the allosteric site of Sos. PMID: 26565026
    12. The present study provides a first evidence of allelic imbalance of SOS1 and pinpoints this condition as a possible mechanism underlying a different penetrance of some SOS1-mutated alleles in unrelated carriers PMID: 25712082
    13. In non-apoptotic cells, nuclear EGFR induced SOS1 expression by directly binding to the SOS1 promoter. PMID: 25980493
    14. rs963731 is associated with corticobasal degeneration. PMID: 26077951
    15. findings suggest that targeting the Src/Abl/Sos1/Rac pathway may represent a double-edged sword to control both cancer-invasive capacities and cancer-related inflammation. PMID: 26447228
    16. These data demonstrated the negative regulation between miR-146a and SOS1 and between miR-370 and GADD45beta and that these regulations are influenced by enterovirus 71 to induce apoptosis. PMID: 25469565
    17. Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme. PMID: 25825487
    18. SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1. PMID: 25394671
    19. HGF-related mutation g.126,142-126,143insC in exon 21 was not found in any of the 6 affected individuals from three families. PMID: 25062969
    20. Stabilized alpha helices of son of sevenless 1 directly inhibit wild-type and mutant forms of KRAS. PMID: 25624485
    21. CIIA functions as a negative modulator of the SOS1-Ras signaling events initiated by peptide growth factors including EGF. PMID: 24522193
    22. Increased expression of SOS1 increases NFkappaB activation in several types of cancer cells, and ablation of SOS1 inhibits EGF-induced NFkappaB activation in these cells, indicating that SOS1 is a component of the pathway connecting EGFR to NFkappaB activation. PMID: 25071181
    23. sustained Erk signaling and T-cell activation depend on both Sos1 and RasGRP1. PMID: 24497027
    24. MiR-124 inhibits the growth of glioblastoma through the downregulation of SOS1. PMID: 23817964
    25. Although Sos1 and Gab1 recognize two non-overlapping sites within the Grb2 adaptor, allostery promotes the formation of two distinct pools of Grb2-Sos1 and Grb2-Gab1 binary signaling complexes in lieu of a composite Sos1-Grb2-Gab1 ternary complex. PMID: 23334917
    26. The SOS1 T158A mutation altered the phosphorylation of gene products involved in both RAS/MAPK and PI3K/AKT pathways. PMID: 23528009
    27. The PR domain displays a highly dynamic conformational basin in agreement with the knowledge that the intrinsically unstructured proteins rapidly interconvert between an ensemble of conformations. PMID: 23528987
    28. study established that the presence of SOS1, but not its enzymatic activity, is critical for p38 activation PMID: 23589333
    29. Oncogenic K-Ras promotes the activation of wild-type H- and N-Ras and this activation is mediated by oncogenic K-Ras-dependent allosteric stimulation of Sos. PMID: 23132018
    30. T-cell antigen receptor (TCR)-mediated Erk activation requires RasGRP1, but not Grb2/Sos. PMID: 22344067
    31. Modeling and simulation of aggregation of membrane protein LAT with molecular variability in the number of binding sites for cytosolic Grb2-SOS1-Grb2 PMID: 22396725
    32. We present a stochastic mathematical model describing intra-molecular regulation of hSos1 activity. PMID: 21851854
    33. multiple binding sites within Sos1 provide a physical route for Grb2 to hop in a flip-flop manner from one site to the next through facilitated diffusion, and such rapid exchange forms the basis of cooperativity driving bivalent binding of Grb2 to Sos1 PMID: 22360309
    34. SOS1 over-expression may play a role in the regulation of the RAS/mitogen-activated protein kinase pathway in the skin, in the hair follicle proliferation and cell cycle, suggesting new perspectives in understanding the pathogenesis of hirsutism. PMID: 22217993
    35. CIIA functions as a molecular switch for the GEF activity of SOS1, directing this activity toward Rac1. PMID: 22042618
    36. The researchers found evidence that there were significant differences between the D2S441 locus in the Maghreb population and other populations. PMID: 21674833
    37. this report expanded the available information about the molecular diversity of SOS1 mutations underlying Noonan syndrome, and have provided a more comprehensive assessment of the clinical features associated with those molecular lesions. PMID: 21387466
    38. Comparison of RasGEF expression at different developmental stages showed that relative to Sos2 and RasGRP1, Sos1 is most abundant in DN thymocytes, but least abundant in DP thymocytes. PMID: 21746917
    39. two unrelated patients with Noonan syndrome carrying the same heterozygous SOS1 missense mutation (c.1867T > A/p.F623I) PMID: 20673819
    40. A case mimicking CS with SOS1 T158A substitution, which has not been reported previously in CS, revealed the complex relationship between the genotype and phenotype of overlapping syndromes of the RAS/RAF/MEK/ERK pathway. PMID: 20030748
    41. This study investigated the regulation of the previously uncharacterized SOS1 gene promoter by the aryl hydrocarbon receptor and its ligands in HepG2 cells. PMID: 20950586
    42. mutation analysis performed on RAF1, SOS1, and GRB2, in 24 Noonan syndrome patients previously found to be negative for PTPN11 and KRAS mutations; SOS1 may have a role of modifier gene that might contribute the variable expressivity of the disease PMID: 20683980
    43. Noonan syndrome is due to a SOS1 missense mutation and rhabdomyosarcoma. PMID: 20607846
    44. Multiple decisive phosphorylation sites for the negative feedback regulation of SOS1 via ERK. PMID: 20724475
    45. Noonan-like/multiple giant cell lesion syndrome with mutations in the SOS1 gene PMID: 20305546
    46. Based on our results, it is possible that a subtle dysfunction (expression) of the SOS1 gene is involved in the development of the most common male reproductive tract disorder - unilateral or bilateral cryptorchidism PMID: 20389169
    47. a new crystal structure of SOS at 3.2 A resolution was presented that contains the histone domain and the DH-PH unit in addition to the catalytic segment (SOSHDPC, residues 1-1049). PMID: 20133692
    48. Sos-histone domain plays a critical role in governing the catalytic output of Sos through the coupling of membrane recruitment to the release of autoinhibition. PMID: 20133694
    49. First report describing different tumor types in Noonan syndrome with germline SOS1 mutations. PMID: 19953625
    50. The binding of Grb2 adaptor to its downstream partners Sos1 and Gab1 docker is under tight allosteric regulation. PMID: 20005866

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  • 相关疾病：
    Fibromatosis, gingival, 1 (GINGF1); Noonan syndrome 4 (NS4)
  • 组织特异性：
    Expressed in gingival tissues.
  • 数据库链接：

    HGNC: 11187

    OMIM: 135300

    KEGG: hsa:6654

    STRING: 9606.ENSP00000384675

    UniGene: Hs.709893