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SORCS1 Antibody

  • 货号：
    CSB-PA848843LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: K562 whole cell lysate
      All lanes: SORCS1 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 130, 134, 132 kDa
      Observed band size: 130 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA848843LA01HU at dilution of 1:100
    • Immunofluorescence staining of MCF-7 cells with CSB-PA848843LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SORCS1 Polyclonal antibody
  • Uniprot No.：
    Q8WY21
  • 基因名：
    SORCS1
  • 别名：
    SORCS1 antibody; SORCS antibody; VPS10 domain-containing receptor SorCS1 antibody; hSorCS antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human VPS10 domain-containing receptor SorCS1 protein (34-175AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SORCS1 Antibody (CSB-PA848843LA01HU)，的标记方式是Non-conjugated。对于SORCS1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA848843LB01HU SORCS1 Antibody, HRP conjugated ELISA
    FITC CSB-PA848843LC01HU SORCS1 Antibody, FITC conjugated
    Biotin CSB-PA848843LD01HU SORCS1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. We report for the first time the relevance of SORCS1 polymorphisms for glycemic control and glucose stimulated insulin secretion in obese women with polycystic ovary syndrome. SORCS1 rs1416406 significantly influenced stimulated glucose plasma levels and increased glucose stimulated insulin secretion PMID: 27052493
    2. Data identified associations between single nucleotide polymorphisms in SORCS1 and renal function in large cohorts of European and African ancestry. PMID: 23780848
    3. The propeptide region of sorCS1 contains two separate sites for binding to sortilin. One of these sites is removed from human sorCS1 during processing. PMID: 24128306
    4. Genetic variation of the rs10884402 and rs950809 in intron 1 of SORCS1 is associated with late onset Alzheimer disease in the Chinese Han population. PMID: 23700427
    5. The genetic link between AD[Alzheimer's disease]and SORCS1 gene variations are influenced by ethnic background, sex and whether an individual has type 2 diabetes mellitus PMID: 23279143
    6. [review] Emerging data from a rapidly growing area of research implicates the Vps10 family of receptors and the retromer in physiological intracellular trafficking by neurotrophins and pathogenesis of neurodegeneration. PMID: 23055476
    7. Our data suggested that SORCS1 was in interaction with APOE in the development of late-onset Alzheimer's disease in a Northern Han Chinese population PMID: 22353753
    8. suggest that genetic variation in SORCS1 is associated with memory performance PMID: 22046233
    9. Dysfunction of SorCS1 may contribute to both the amyloid precursor protein/amyloidbeta disturbance underlying Alzheimer disease and the insulin/glucose disturbance underlying diabetes mellitus. PMID: 20881129
    10. SNP which is nearest to SORCS1 is highly significantly associated with glycemic control in individuals with type 1 diabetes PMID: 19875614
    11. human sorCS1 has three isoforms, sorCS1a-c, with completely different cytoplasmic tails and differential expression in tissues PMID: 12482870
    12. Different motifs regulate trafficking of SorCS1 isoforms. PMID: 18315530
    13. SORCS1 SNPs show genotypic association with Alzheimer disease. PMID: 19241460

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    VPS10-related sortilin family, SORCS subfamily
  • 组织特异性：
    Detected in fetal and infant brain and in fetal retina.
  • 数据库链接：

    HGNC: 16697

    OMIM: 606283

    KEGG: hsa:114815

    STRING: 9606.ENSP00000345964

    UniGene: Hs.591915