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SORBS3 Antibody

  • 货号：
    CSB-PA022406LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: SORBS3 antibody at 8µg/ml + HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 76, 37 kDa
      Observed band size: 76 kDa
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA022406LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA022406LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SORBS3 Polyclonal antibody
  • Uniprot No.：
    O60504
  • 基因名：
    SORBS3
  • 别名：
    SORBS3 antibody; SCAM1 antibody; Vinexin antibody; SH3-containing adapter molecule 1 antibody; SCAM-1 antibody; Sorbin and SH3 domain-containing protein 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Vinexin protein (1-329AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SORBS3 Antibody (CSB-PA022406LA01HU)，的标记方式是Non-conjugated。对于SORBS3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA022406LB01HU SORBS3 Antibody, HRP conjugated ELISA
    FITC CSB-PA022406LC01HU SORBS3 Antibody, FITC conjugated
    Biotin CSB-PA022406LD01HU SORBS3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.
  • 基因功能参考文献：
    1. Vinexin beta deficiency attenuates atherogenesis primarily by suppressing vascular inflammation and inactivating Akt-nuclear factor kappaB signaling. Our data suggest that vinexin beta could be a therapeutic target for the treatment of atherosclerosis. PMID: 28209562
    2. The chromosome 8p tumor suppressor genes SORBS3 and SH2D4A are physically and functionally linked and provide a molecular mechanism of inhibiting STAT3-mediated IL-6 signaling in hepatocellular carcinoma cells. PMID: 27311882
    3. Study identified possible epigenetic influence on differential gene expression in SORBS3 under obese conditions. PMID: 27437034
    4. Our findings revealed that Vinexin-beta acts as a novel modulator of ischaemic injury PMID: 25824575
    5. Taken together, the findings suggest that vinexin beta modulates NS5A phosphorylation via its interaction with NS5A, thereby regulating hepatitis C virus replication, implicating vinexin beta in the viral life cycle. PMID: 25972535
    6. Vinexin knockdown using siRNA delayed migration of both HaCaT human keratinocytes and A431 epidermoid carcinoma cells in scratch assay but did not affect cell proliferation. PMID: 20361963
    7. regulates cytoskeletal organization and signal transduction--review PMID: 12510380
    8. vinexin is a novel substrate of ERK2 and may play roles in ERK-dependent cell regulation PMID: 15184391
    9. phosphorylation of the AF-1 domain controls RARgamma-mediated transcription through triggering the dissociation of vinexin beta PMID: 15734736
    10. These results suggest that vinexin beta plays a role in maintaining the phosphorylation of EGFR on the plasma membrane through the regulation of c-Cbl. PMID: 16923119
    11. Vinexin is enriched at the leading edge of migrating cells, lamellipodia and and focal adhesions in well-spread cells. PMID: 17486060
    12. Rhotekin forms a complex with vinexin and may play a role at focal adhesions. PMID: 19294487

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  • 亚细胞定位：
    [Isoform Alpha]: Cell junction. Cytoplasm, cytoskeleton.; [Isoform Beta]: Cell junction. Nucleus. Cytoplasm, cytoskeleton.
  • 组织特异性：
    Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver.
  • 数据库链接：

    HGNC: 30907

    OMIM: 610795

    KEGG: hsa:10174

    STRING: 9606.ENSP00000240123

    UniGene: Hs.528572