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  4. SOCS2 Antibody

SOCS2 Antibody

  • 货号：
    CSB-PA158942
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA158942(SOCS2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    O14508
  • 基因名：
  • 别名：
    CIS 2 antibody; CIS-2 antibody; CIS2 antibody; Cish 2 antibody; Cish2 antibody; Cytokine inducible SH2 protein 2 antibody; Cytokine-inducible SH2 protein 2 antibody; SOCS 2 antibody; SOCS-2 antibody; Socs2 antibody; SOCS2_HUMAN antibody; SSI 2 antibody; SSI-2 antibody; SSI2 antibody; STAT induced STAT inhibitor 2 antibody; STAT-induced STAT inhibitor 2 antibody; STATI 2 antibody; STATI2 antibody; Suppressor of cytokine signaling 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human SOCS2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
  • 基因功能参考文献：
    1. SOCS2 impairs IFN/JAK/STAT signaling through reducing the stability of tyrosine kinase 2 (TYK2), downregulating the expression of type I and III IFN receptors, attenuating the phosphorylation and nucleus translocation of STAT1. PMID: 28496097
    2. High SOCS2 expression is associated with higher grade breast cancer. PMID: 30453988
    3. Study provides evidence for an inhibitory role of SOCS2 in TNFalpha induced NF-kappa B activation, identifies NDR1 as a novel substrate of SOCS2, and demonstrates that SOCS2 and TNFalpha induced NF-kappa B signaling are linked through NDR1. PMID: 28216640
    4. Overexpression of miR-196b suppresses SOCS2 in human laryngeal squamous cell carcinoma resulting in tumor progression and poor prognosis. PMID: 29753737
    5. Methyltransferase-like 3 represses SOCS2 expression in hepatocellular carcinoma through an m6A-YTHDF2-dependent mechanism. Our findings suggest an important mechanism of epigenetic alteration in liver carcinogenesis PMID: 29171881
    6. Study in lung cancer BEAS-2B cells shows that SOCS2 binding to the growth hormone receptor (GHR) is impaired by a GHR threonine substitution at Pro 495. This results in decreased internalisation and degradation of the receptor. PMID: 28967904
    7. Despite of the key role of SOCS2 in the regulation of GH receptor signaling, study did not find any significant association between SOCS2 polymorphisms and acromegaly. PMID: 27900634
    8. The induction of a tolerogenic phenotype in DCs by NPs was mediated by the AhR-dependent induction of Socs2, which resulted in inhibition of nuclear factor kappaB activation and proinflammatory cytokine production (properties of tolerogenic DCs). PMID: 27330188
    9. Long-term palmitate treatment up-regulates SOCS2 and reduces PI3K activity, thereby impairing glucose stimulated insulin secretion. PMID: 27566229
    10. Targeting of SOCS2 by miR-194 resulted in derepression of the oncogenic kinases FLT3 and JAK2, leading to enhanced ERK and STAT3 signaling. PMID: 28011622
    11. Single-cell RNA sequencing reveals enrichment of homeostatic modules in monocytes and dendritic cells from human metastatic melanoma. Suppressor-of-cytokine-2 (SOCS2) protein, a conserved program transcript, is expressed by mononuclear phagocytes infiltrating primary melanoma and is induced by IFNgamma. PMID: 28666115
    12. this study shows that IL-7 induces the expression of SOCS2 through the JAK/STAT-5 pathway and that SOCS2 interacts with CD127 in early endosomes and direct the receptor complex to the proteasome for degradation PMID: 27423467
    13. Overexpression of SOCS2 inverted these phenotypes generated by hsv2-miR-H9-5p, indicating the potential roles of SOCS2 in Hsv2-miR-H9-5p-driven metastasis in lung cancers. The results highlighted that Hsv2-miR-H9-5p regulated and contributed to bone metastasis of lung cancers. We proposed that Hsv2-miR-H9-5p could be used as a potential target in lung cancer therapy PMID: 28468588
    14. Overexpression of SOCS-2 is associated with hepatocellular carcinoma. PMID: 27465557
    15. focus on SOCS2 and review its biological function as well as its implication in pathological processes PMID: 26709655
    16. SOCS2 may improve outcome of TBI in mice by regulating aspects of the neuroinflammatory response PMID: 27071013
    17. This study showed that there was significantly increased levels of SOCS-2 mRNA in elderly and Alzheimer's disease brains. PMID: 25286386
    18. crystals of SOCS2 in complex with its adaptor proteins, Elongin C and Elongin B, underwent a change in crystallographic parameters when treated with dimethyl sulfoxide during soaking experiments. PMID: 26121586
    19. miR-101 functions as a growth-suppressive miRNA in H. pylori related GC, and that its suppressive effects are mediated mainly by repressing SOCS2 expression. PMID: 25561270
    20. our study indicates that high SOCS2 expression is associated with poor survival in pediatric AML. PMID: 24559289
    21. This study shows that over-expression of SOCS2 reduces the psychostimulant effects of amphetamine, enhances PPI, and alters mesolimbic dopaminergic activity. PMID: 25283341
    22. The SOCS2 polymorphism (rs3782415) has an influence on the adult height of children with Turner syndrome and growth hormone deficiency after long-term therapy. PMID: 24905066
    23. SOCS2 correlates with malignancy and exerts growth-promoting effects in prostate cancer. PMID: 24280133
    24. Stage-independent downregulation of SOCS2 and SOCS6 correlate with disease-free survival in colorectal cancer. PMID: 25025962
    25. SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer. PMID: 24031028
    26. SOCS2 associates with activated FLT3 through phosphotyrosine residues 589 and 919, and co-localizes with FLT3 in the cell membrane. PMID: 23548639
    27. Estradiol can amplify GH intracellular signaling in human osteoblasts with an essential role played by the reduction of the SOCS2 mediated feedback loop. PMID: 23567159
    28. SOCS2 and SOCS6 expression are remarkably reduced in hepatocellular carcinoma and correlate with aggressive tumor progression and poor prognosis PMID: 23475171
    29. Simultaneous stimulation of monocyte-derived DCs resulted in highly increased production of IL-1beta, IL-23 and SOCS2. PMID: 22795647
    30. Data demonstrated that suppressor of cytokine signaling 2 (SOCS2) protein level was distinctively increased by saponin, which in turn resulted in inhibition of HCV replication. PMID: 22745742
    31. High SOCS2 is associated with idiopathic short stature. PMID: 22768656
    32. LPS regulates SOCS2 transcription in a type I interferon dependent autocrine-paracrine loop. PMID: 22291912
    33. We propose a model in which SOCS2 acts as a negative regulator of TLR-induced dendritic cell activation PMID: 21844389
    34. Data show that knockdown of SOCS2 resulted in the accumulation of p-Pyk2(Tyr402) and blocked NK cell effector functions. PMID: 20543098
    35. Probiotic administration increased expression of SOCS-2 and SOCS-3 in Helicobacter pylori infection to limit inflammatory signaling. PMID: 20136974
    36. SOCS2 is required for appropriate TLR4 signaling in maturating human DCs via both the MyD88-dependent and -independent signaling pathway PMID: 19779605
    37. SOCS-2 is overexpressed in advanced stages of chronic myeloid leukemia. It may be a component of a negative feedback mechanism that is functioning inadequately, induced by Bcr-Abl but unable to reverse its growth-promoting effects. PMID: 11861294
    38. SOCS2 mediates the suppression of JAK2 phosphorylation by estrogen, which inhibits growth hormone signaling PMID: 12552091
    39. Association of single-nucleotide polymorphisms in the SOCS2 gene with type 2 diabetes in the Japanese was studied. PMID: 16406727
    40. Results describe the 1.9-A crystal structure of the ternary complex of SOCS2 with elongin C and elongin B. PMID: 16675548
    41. SOCS2 only interacts with the Y1077 motif, but with higher binding affinity and can interfere with CIS and STAT5a prey recruitment at this site. PMID: 16684815
    42. Using RT-PCR, we demonstrated for the first time that neutrophils express mRNA for SOCS-2. PMID: 17264307
    43. A defect in expression of SOCS-2 and SOCS-3 genes may be crucial for the IGF-I hypersensitivity and progressive increase in erythroid cell population size characteristic of Polycythemia vera. PMID: 17325857
    44. Favorable prognostic value of high SOCS2 expression in primary mammary carcinomas. PMID: 17651480
    45. analysis of STAT5, CIS, and SOCS2 interactions with the growth hormone receptor PMID: 17666591
    46. SOCS2 epigenetic downregulation might be an important second step in the genesis of cytokine-independent myeloproliferative disorder clones PMID: 18769447
    47. Acromegalic patients with active disease and hyperplastic polyps had higher levels of SOCS2 transcripts. PMID: 18844680
    48. role of SOCS-2 in mediating HIV-1-induced immune evasion and dysregulation of IFNgamma signaling in primary human monocytes PMID: 19279332
    49. SOCS2 expression is regulated by STAT5. PMID: 17008382

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  • 组织特异性：
    High expression in heart, placenta, lung, kidney and prostate. Predominantly expressed in pulmonary epithelia cells, specifically type II pneumocytes.
  • 数据库链接：

    HGNC: 19382

    OMIM: 605117

    KEGG: hsa:8835

    STRING: 9606.ENSP00000339428

    UniGene: Hs.485572