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SNRPE Antibody

  • 货号：
    CSB-PA022336LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: K562 whole cell lysate, HepG2 whole cell lysate
      All lanes: SNRPE antibody at 5.2µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 11 kDa
      Observed band size: 11 kDa
    • IHC image of CSB-PA022336LA01HU diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of U251 cells with CSB-PA022336LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SNRPE Polyclonal antibody
  • Uniprot No.：
    P62304
  • 基因名：
    SNRPE
  • 别名：
    AL022645 antibody; B raf antibody; B-raf antibody; Braf antibody; C76690 antibody; HYPT11 antibody; RUXE_HUMAN antibody; Sm protein E antibody; Sm-E antibody; Small nuclear ribonucleoprotein E antibody; SmE antibody; snRNP-E antibody; snRNPE antibody; snrpe antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Small nuclear ribonucleoprotein E protein (1-92AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SNRPE Antibody (CSB-PA022336LA01HU)，的标记方式是Non-conjugated。对于SNRPE Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA022336LB01HU SNRPE Antibody, HRP conjugated ELISA
    FITC CSB-PA022336LC01HU SNRPE Antibody, FITC conjugated
    Biotin CSB-PA022336LD01HU SNRPE Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
  • 基因功能参考文献：
    1. Overexpression of SNRPE is associated with highly aggressive breast cancers. PMID: 23358685
    2. Mutations in SNRPE, which encodes a core protein of the spliceosome, cause autosomal-dominant hypotrichosis simplex PMID: 23246290
    3. In the SME intron, the position of the branchpoint A residue within the region base paired with U12 differs from that in P120 and XTF. PMID: 12022225
    4. growth arrest by SmE directly correlates with the reduction of cyclin E, CDK2, CDC25C and CDC2 expression, and up-regulation of p27Kip PMID: 18208561
  • 相关疾病：
    Hypotrichosis 11 (HYPT11)
  • 亚细胞定位：
    Cytoplasm, cytosol. Nucleus.
  • 蛋白家族：
    SnRNP Sm proteins family
  • 组织特异性：
    Widely expressed. In scalp skin, it is present in the hair follicle, the epidermis, and the dermis.
  • 数据库链接：

    HGNC: 11161

    OMIM: 128260

    KEGG: hsa:6635

    STRING: 9606.ENSP00000400591

    UniGene: Hs.334612