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  4. SNIP1 Antibody

SNIP1 Antibody

  • 货号：
    CSB-PA021931GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8TAD8
  • 基因名：
  • 别名：
    FHA domain containing protein SNIP1 antibody; FHA domain-containing protein SNIP1 antibody; FLJ12553 antibody; PMRED antibody; Smad nuclear interacting protein (Smad nuclear interacting) antibody; smad nuclear interacting protein 1 antibody; Smad nuclear interacting protein antibody; Smad nuclear-interacting protein 1 antibody; SNIP1 (Smad nuclear interacting protein) antibody; SNIP1 antibody; SNIP1_HUMAN antibody; Splicing factor arginine/serine rich 4 (Pre mRNA splicing factor SRP75) antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SNIP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for pre-mRNA splicing as component of the spliceosome. Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.
  • 基因功能参考文献：
    1. these data demonstrated a novel mechanism whereby SNIP1 regulates intestinal inflammation through modulating intestinal epithelial barrier function PMID: 29426045
    2. SUMOylation of SNIP1 leads to the loss of SNIP1-mediated inhibition on expression of the TGF-beta target genes PAI-1 and MMP2 and eventually enhances TGF-beta-regulated cell migration and invasion. PMID: 27703003
    3. Involvement of SNIP1 in progression of lung cancer by regulating the RB/HDAC1 interaction. PMID: 23932364
    4. SNIP1 in cells strongly activated the heat shock element signaling pathway, and SNIP1 might selectively regulate the transcription of some heat shock proteins through associating with heat shock elements PMID: 22020748
    5. Study identified sequence variants in the known disease-causing genes SLC6A3 and FLVCR1, and present evidence to strongly support the pathogenicity of variants identified in TUBGCP6, BRAT1, SNIP1, CRADD, and HARS. PMID: 22279524
    6. overexpression of HIF-1alpha, TWIST2 or SNIP1 correlated with poor disease-free survival in patients with tongue squamous cell carcinoma PMID: 21167768
    7. define both a new function for SNIP1 and identify a previously unrecognized regulator of the cell cycle and cyclin D1 expression PMID: 15378006
    8. Smad-binding peptide aptamers can be developed to selectively inhibit TGF-beta-induced gene expression. PMID: 15750622
    9. SNIP1 functions as a regulator of c-Myc activity, binding the N c-Myc N terminus through its C terminus, and that SNIP1 enhances the transcriptional activity of c-Myc by stabilizing it against proteosomal degradation and bridging the c-Myc/p300 complex. PMID: 17157259
    10. SNIP1, the human homolog of DDL, is involved in miRNA biogenesis and interacts with Drosha PMID: 18632581
    11. Study shows a novel mechanism regulating Cyclin D1 expression and offers new insight into the role of SNIP1 and associated proteins as regulators of proliferation and cancer. PMID: 18794151

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  • 相关疾病：
    Psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED)
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Ubiquitous, with highest expression in heart and skeletal muscle.
  • 数据库链接：

    HGNC: 30587

    OMIM: 608241

    KEGG: hsa:79753

    STRING: 9606.ENSP00000296215

    UniGene: Hs.47232