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SNCAIP Antibody

  • 货号：
    CSB-PA896546LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA896546LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA896546LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA896546LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SNCAIP Polyclonal antibody
  • Uniprot No.：
    Q9Y6H5
  • 基因名：
    SNCAIP
  • 别名：
    Alpha synuclein interacting protein antibody; Alpha-synuclein-interacting protein antibody; MGC39814 antibody; SNCAIP antibody; SNCAP_HUMAN antibody; Sph1 antibody; Synphilin-1 antibody; Synphilin1 antibody; Synuclein alpha interacting protein (synphilin) antibody; Synuclein alpha interacting protein antibody; SYPH 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Synphilin-1 protein (309-553AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SNCAIP Antibody (CSB-PA896546LA01HU)，的标记方式是Non-conjugated。对于SNCAIP Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA896546LB01HU SNCAIP Antibody, HRP conjugated ELISA
    FITC CSB-PA896546LC01HU SNCAIP Antibody, FITC conjugated
    Biotin CSB-PA896546LD01HU SNCAIP Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1.
  • 基因功能参考文献：
    1. Differential expression of synphilin-1 isoforms (and alpha-synuclein and parkin) was found in multiple system atrophy brains compared to control brain. PMID: 26465922
    2. Synphilin-1 binds ATP, but not CTP. PMID: 25545246
    3. Overexpression of human synphilin-1 in mice resulted in hyperphagia and obesity. PMID: 24829096
    4. Overexpression of SP1 in neurons, but not peripheral cells, increased the body weight of flies compared with that of non-transgenic controls. SP1 increased food intake but did not affect locomotor activity PMID: 22828940
    5. Although serine-129 phosphorylation of alpha-synuclein facilitates tubulin polymerization promoting protein (TPPP)-mediated alpha-SYN oligomerization, this modification does not seem to play an inevitable role in the early step of alpha-SYN oligomer formation. PMID: 20849899
    6. Mutation screening of SNCAIP identifies novel sequence variants using a bioinformatic approach; further studies are necessary to determine their possible functional consequences in South African patients with Parkinson's disease. PMID: 21344240
    7. Neuronal survival factor MEF2D is decreased in human and experimental Parkinson's disease, a decrease that is specifically associated with alpha-synuclein accumulation and aggregation. PMID: 20816781
    8. Synphilin-1 inhibits alpha-synuclein degradation by the proteasome. PMID: 21103907
    9. Knockdown of Herp gene unexpectedly facilitated the degradation of synphilin-1, and improved cell viability during proteasomal inhibition. PMID: 20604806
    10. Data show that periphilin displays an overlapping expression pattern with synphilin-1 in cellular and animal models and in Lewy bodies of Parkinson's disease (PD) patients, and support involvement of periphilin in PD. PMID: 19730898
    11. expression of synphilin-1 shortens N1E-115 cell division doubling time, promotes neurite outgrowth, and protects against Rotenone-induced toxicity; synphilin-1 displays a neurotrophic effect in vitro, may play a neuroprotective role in Parkinson's disease PMID: 19857556
    12. alpha-synuclein-synphilin-1 interaction significantly promotes the formation of cytoplasmic alpha-synuclein inclusions, which may have implications for Lewy body formation in neural cells PMID: 19762560
    13. The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain. Expression of mouse synphilin-1 in tissues is similar to its human counterpart. PMID: 11958831
    14. results suggest that synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1 PMID: 12750386
    15. a causative role of the R621C mutation in the synphilin-1 gene in Parkinson's disease PMID: 12761037
    16. Changes in synuclein expression presage neurodegeneration in a Drosophila model of Parkinson disease. PMID: 12915459
    17. Siah-1 was found to abrogate the inhibitory effects of synphilin-1 on dopamine release PMID: 14506261
    18. role of aggresomes in cell viability was addressed in the context of over-expressing alpha-synuclein and its interacting partner synphilin-1 PMID: 14627698
    19. Casein kinase II (CKII) phosphorylates synphilin-1; beta subunit of this enzyme complex binds to synphilin-1. CKII-mediated phosphorylation of synphilin-1, rather than alpha-synuclein, modulates the aggregation into inclusion bodies. PMID: 14645218
    20. role of synphilin-1 in synaptic function and protein degradation and in the molecular mechanisms leading to neurodegeneration in Parkinson disease PMID: 15322916
    21. Parkin is a dual-function ubiquitin ligase. K63-linked ubiquitination of synphilin-1 by parkin may be involved in the formation of Lewy body inclusions associated with Parkinson disease. PMID: 15728840
    22. We confirm that synphilin-1 and parkin are components of majority of Lewy Bodies in Parkinson's disease and that both proteins are susceptible to proteasomal degradation. PMID: 15894486
    23. GSK3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH PMID: 16174773
    24. Synphilin-1A may contribute to neuronal degeneration in alpha-synuclein mutations and provides insights into the role of inclusion bodies in neurodegenerative disorders. PMID: 16595633
    25. These results suggest that NUB1 indeed targets synphilin-1 to the proteasome for its efficient degradation, which, because of the resultant reduction in synphilin-1, suppresses the formation of synphilin-1-positive inclusions. PMID: 16877356
    26. a novel specific interaction of synphilin-1 with the regulatory proteasomal protein S6 ATPase (tbp7) in aggresome-like intracytoplasmic inclusions PMID: 17327361
    27. These findings suggest that parkin and synphilin-1 isoform expression changes play a significant role in the pathogenesis of LB diseases. PMID: 17467279
    28. review:Isoform Synphilin-1A inclusions recruit both alpha-synuclein and synphilin-1. Aggregation of synphilin-1 and synphilin-1A seems to be protective to cells PMID: 17982729
    29. specific effects of C621 mutant synphilin-1 on gene expression that correlate with its role as a susceptibility factor in Parkinson's disease PMID: 18292964
    30. All four alpha-synuclein isoforms were affected in dementia with LB (Lewy bodies), most parkin transcript variants in common LB disease, and all synphilin-1 isoforms in Parkinson disease. PMID: 18335262
    31. We found no evidence for association between genetic variability in synphilin-1 and Parkinson's disease PMID: 18366718
    32. translocation to aggresomes required a special aggresome-targeting signal within the sequence of synphilin 1, an ankyrin-like repeat domain. PMID: 18635553
    33. Synphilin-1 might be involved in motor function, and its accumulation in the central nervous system can cause motor impairments. PMID: 18782602
    34. synphilin-1A has a novel role as a regulator of SIAH activity, modulating alpha-synuclein, and formation of Lewy body-like inclusions PMID: 19224863

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  • 相关疾病：
    Parkinson disease (PARK)
  • 亚细胞定位：
    Cytoplasm. Note=Detected in cytoplasmic inclusion bodies, together with SNCA.
  • 组织特异性：
    Detected in brain (at protein level). Widely expressed, with highest levels in brain, heart and placenta.
  • 数据库链接：

    HGNC: 11139

    OMIM: 168600

    KEGG: hsa:9627

    STRING: 9606.ENSP00000261368

    UniGene: Hs.426463