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  4. SNAI1 (Ab-246) Antibody

SNAI1 (Ab-246) Antibody

  • 货号：
    CSB-PA041790
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from HT29 cells, using SNAI1 (Ab-246) antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SNAI1 Polyclonal antibody
  • Uniprot No.：
    O95863
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized non-phosphopeptide derived from Human SNAI1 around the phosphorylation site of serine 246 (T-F-S(p)-R-M).
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription. SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
  • 基因功能参考文献：
    1. Snail1 gene silencing effectively improved the drug sensitivity of MMCs to bortezomib chemotherapy. PMID: 30365089
    2. Up-regulation of long non-coding RNA XLOC_010235 regulates epithelial-to-mesenchymal transition to promote metastasis by associating with Snail1 in gastric cancer. PMID: 28550287
    3. Study provides evidence that genetic variants in SNAI1 and TWIST1 are associated with breast cancer (BC) and ovarian cancer (OC) susceptibility and suggests a synergistic effect of those related loci on BC/OC risk. PMID: 30272327
    4. Ovarian cancer patients show elevated serum CXCL1/2, which correlates with Snail expression, myeloid-derived suppressor cells infiltration, and short overall survival. Snail induces ovarian cancer progression via upregulation of CXCR2 ligands and recruitment of myeloid-derived suppressor cells. PMID: 29703902
    5. The s identify SNAI1 as the key Epithelial-Mesenchymal Transition transcriptional factor required for the specification of definitive endoderm. PMID: 28466868
    6. Snail functions as a metabolic switch between aerobic glycolysis and pentose phosphate pathway by repressing PFKP, a cancer-specific PFK-1, allowing cancer cell survival under metabolic stress. PMID: 28176759
    7. At the molecular level, transcription of the adherens junction protein E-cadherin is upregulated on nicotinic acid addition, leading to accumulation of E-cadherin protein at the cell-cell boundary. This can be attributed to nicotinic acid's ability to facilitate the ubiquitination and degradation of Snail1, a transcription factor that represses E-cadherin expression. PMID: 28256591
    8. Dub3 is identified as a bona fide Snail1 deubiquitinase, which interacts with and stabilizes Snail1. PMID: 28198361
    9. High SNAIL1 expression is associated with breast invasive ductal carcinoma. PMID: 29937187
    10. The present study illustrated that downregulation of CDK10 expression activated Snaildriven EMT and consequently promoted glioma metastasis, suggesting that CDK10 may serve as a potential molecular target for glioma therapy. PMID: 29845196
    11. Binding of HIV1 Tat to TIP30 enhanced epithelial-to-mesenchymal transition and metastasis by regulating the nuclear translocation of Snail. PMID: 30099830
    12. Chronic hypoxia-induced slug promotes invasive behavior of prostate cancer cells by activating the expression of ephrin-B1. PMID: 30058095
    13. FBXW7 conduction of tumour suppression was partly through degrading Snai1 directly for ubiquitylating regulation in NSCLC. PMID: 30094882
    14. It is concluded that epithelial-mesenchymal transition is involved in human diabetic cataract, and upregulation of miR-30a can repress epithelial-mesenchymal transition through its targeting of SNAI1 in lens epithelial cells, which make miR-30a a novel target of therapeutic intervention for human diabetic cataract. PMID: 28442786
    15. irradiation of Human Umbilical Vein Endothelial Cells induced the differentiation of fibroblasts into myofibroblasts through the Snail/miR-199a-5p axis. PMID: 29619372
    16. these results indicate that miR124 transection inhibits the growth and aggressive of osteosarcoma, potentially via suppression of TGFbetamediated AKT/GSK3beta/snail family transcriptional repressor 1 (SNAIL1) signaling, suggesting miR124 may be a potential anticancer agent/target for osteosarcoma therapy. PMID: 29488603
    17. MiR-30c inhibits ESCC biological behaviors and EMT progress by directly binding to the 3'-UTR of SNAI1. PMID: 29304493
    18. MiR-22 over-expression attenuated lung cancer cell EMT and invasion via targeted inhibiting Snail. PMID: 28925484
    19. High glucose enhances the formation of EZH2/Snail/HDAC1 complex in the nucleus, which in turn causes E-cadherin repression. PMID: 29705809
    20. Neutrophils and Snail orchestrate the establishment of a pro-tumor microenvironment in lung cancer. PMID: 29241546
    21. Snail-1 plays a major role in the progression and migration of urinary bladder cancer. PMID: 29032338
    22. In patients with gastric cancer, the positive-to-negative conversion of the Snail status-between primary tumors and lymph node metastasis may be important for confirming epithelial-mesenchymal transition and mesenchymal-epithelial transition. PMID: 28247164
    23. Inhibition of cell migration, invasion, and metastasis in esophageal carcinoma requires CBX8-mediated repression of Snail. PMID: 28912889
    24. Dermal fibroblast-to-myofibroblast transition sustained by alphavss3 integrin-ILK-Snail1/Slug signaling is a common feature for hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders. PMID: 29309923
    25. increased abundance of Snail and Axin2 is highly correlated to malignant transformation of OL, making them novel biomarker(s) predicting oral cancer development PMID: 28939076
    26. FoxM1 may enhance the invasion and migration of cancer cells, and thus promotes their Epithelialmesenchymal transition, in a mechanism that may involve the regulation of Snai1. PMID: 28849004
    27. High SNAIL expression is associated with invasion, metastasis, and epithelial-to-mesenchymal transition of gastric cancer. PMID: 28424413
    28. Twist1 and Snail1 expression levels were associated with lymphovascular space invasion, lymph node metastasis and histological grade in cervical squamous cell carcinoma. PMID: 29101499
    29. Data show that miR-153 was found to target the 3'-UTR of snail transcription factors (Snail) mRNA. PMID: 28459992
    30. VEGFA and Snail-1 induction by meningitic Escherichia coli mediates disruption of the blood-brain barrier PMID: 27588479
    31. miR-199a-5p inhibited the progression of PTC by downregulating SNAI1, offering new insight into the molecular mechanism underlying PTC progression. PMID: 29427661
    32. our results suggest that Cx32 inhibits Hepatocellular carcinoma (HCC) invasion and metastasis through Snail-mediated EMT, Cx32 and this signaling pathway molecules may offer potential targets for HCC cancer therapy PMID: 28498415
    33. RND3 promotes Snail 1 protein degradation in glioblastoma tumor cells, promoting cell migration and neoplasm invasiveness. PMID: 27705942
    34. this study shows that EGF induces epithelial-mesenchymal transition through phospho-Smad2/3-Snail signaling pathway in breast cancer cells PMID: 27829223
    35. SNAI1 is a direct and functional target of miR-182. However SNAI1 negatively regulates the expression of miR-182 in breast cancer cells. PMID: 27894095
    36. E-cadherin expression was increased by transfection of p300 small interfering RNA in a dose-dependent manner.. There was a correlation between Snail and p300 expressions in lung cancer. Moreover, p300 acetylates Snail both in vivo and in vitro, and K187 may be involved in this modification. PMID: 28296173
    37. PARP3 controls of TGFbeta-induced epithelial mesenchymal transformation and acquisition of stem-like cell features by stimulation transglutaminase 2/SNAI1 signaling. PMID: 27579892
    38. Results show that Snai1 binds to the PXDN promoter in response to TGF-beta1 treatment of cervical carcinoma cell lines and represses its expression. PMID: 29305973
    39. increased Snail expression during progression to metastatic disease may prime cells for resistance to AR-targeted therapies by promoting AR activity in prostate cancer PMID: 27409172
    40. Snail1 may be a co-factor of TERT enhancer rs2853677 for predicting lung adenocarcinoma susceptibility and prognosis PMID: 27191258
    41. Snail-1 might play an important role in the progression of bladder cancer PMID: 27322434
    42. Study demonstrated in human breast cancer samples that MDM2 induces epithelial-to-mesenchymal transition by enhancing Snail expression in vitro and in vivo. PMID: 27184007
    43. Amla extract (Emblica officinalis, AE) decreases the gene and protein expression of IGF1R, a target of miR-375, and SNAIL1, a transcription factor that represses E-cadherin expression. PMID: 27129171
    44. The results demonstrate that knockdown of Snail can inhibit the inhibits epithelial-mesenchymal transition process of laryngeal squamous cell carcinoma cells through the vitamin D receptor signaling pathway in vitro. PMID: 28806534
    45. By repressing FOXA family members, SNAIL1 targets transcription factors at strategically important positions in gene-regulatory hierarchies, which may facilitate transcriptional reprogramming during EMT. PMID: 29155818
    46. Results show that Snail is a direct target of miR-137 and miR-34a in ovarian cancer cells. PMID: 27596137
    47. Results show that Snail1 transcriptional activation is regulated by SOX3 via binding to its promoter region in osteosarcoma cells promoting migration, invasiveness, and EMT. PMID: 28335789
    48. Cten-Snail signaling pathway contributes to cell motility in colorectal cancer (CRC), mediated by the stabilization of Snail protein. PMID: 28691764
    49. Mechanistic investigations found that quercetin suppressed Snail-dependent Akt activation by upregulating maspin and Snail-independent a disintegrin and metalloproteinase (ADAM) 9 expression pathways to modulate the invasive ability of NSCLC cells PMID: 28648644
    50. There was a significant stepwise increase of upgrading rate according to Snail1 expression in DCIS cells: weak 9%, intermediate 26%, and strong 55%, respectively. PMID: 28570750

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Snail C2H2-type zinc-finger protein family
  • 组织特异性：
    Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.
  • 数据库链接：

    HGNC: 11128

    OMIM: 604238

    KEGG: hsa:6615

    STRING: 9606.ENSP00000244050

    UniGene: Hs.48029