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  4. SMARCD3 Antibody

SMARCD3 Antibody

  • 中文名称：
    SMARCD3兔多克隆抗体
  • 货号：
    CSB-PA021810GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q6STE5
  • 基因名：
    SMARCD3
  • 别名：
    60 kDa BRG 1/Brm associated factor subunit C antibody; 60 kDa BRG-1/Brm-associated factor subunit C antibody; BAF60C antibody; BRG1 associated factor 60C antibody; BRG1-associated factor 60C antibody; Chromatin remodeling complex BAF60C subunit antibody; CRACD3 antibody; Mammalian chromatin remodeling complex BRG1 associated factor 60C antibody; MGC111010 antibody; Rsc6p antibody; Smarcd3 antibody; SMRD3_HUMAN antibody; SWI/SNF complex 60 kDa subunit C antibody; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily d member 3 antibody; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3, isoform 1 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 antibody; Swp73 like protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SMARCD3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
  • 基因功能参考文献：
    1. Data show that the combination of GATA binding protein 4 (Gata4), T-box transcription factor 5 (Tbx5) and BRG1-associated factor 60C protein (Baf60c) is sufficient for inducing adipose tissue-derived mesenchymal stem cells (ADMSCs) to form cardiomyocytes. PMID: 26071180
    2. Inhibition of Wnt5a by either RNAi knockdown or blocking antibody reversed Smarcd3 -induced epithelial-mesenchymal transition. Thus, Smarcd3 epigenetically regulates epithelial-mesenchymal transition by activating WNT signaling pathways. PMID: 23716599
    3. Deptor is induced by the Baf60c-Six4 transcriptional complex and mediates activation of Akt and glycolytic metabolism by Baf60c in a cell-autonomous manner PMID: 23563706
    4. BAF60c promotes lipogenesis in vivo and increases triglyceride levels, demonstrating its role in metabolic adaption to activate the lipogenic program in response to feeding and insulin. PMID: 23219531
    5. Data show a combination of only five genes (-BCL6, T (BRACHYURY), c-MYC, MITF and BAF60C (SMARCD3) rapidly and efficiently convert postnatal chorion and decidual cells into chondrocytes. PMID: 22833560
    6. BAF60c phosphorylation on a conserved threonine is the signal that promotes incorporation of MyoD-BAF60c into a Brg1-based SWI/SNF complex, which remodels the chromatin & activates transcription of MyoD-target genes. PMID: 22068056
    7. GTNB directs cardiogenesis from human embryonic stem cells and induces correct cardiac development. PMID: 21694703
    8. BAF60c represents a new coregulator that constitutes an important anchoring point by which the SWI/SNF complex is recruited to nuclear receptors and other transcription factors PMID: 14701856
    9. Tat-mediated activation of the HIV promoter requires the SWI/SNF complex in synergy with the coactivator p300. PMID: 16687403
    10. Baf60c is re-expressed in the Muller glial cells that re-enter the cell cycle after neurotoxic damage PMID: 18816825

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    SMARCD family
  • 组织特异性：
    Isoform 2 and isoform 1 are expressed in brain, heart, kidney, placenta, prostate, salivary gland, spleen, testis, thyroid, trachea and uterus. Isoform 1 is also expressed in skeletal muscle and adipose tissue.
  • 数据库链接：

    HGNC: 11108

    OMIM: 601737

    KEGG: hsa:6604

    STRING: 9606.ENSP00000262188

    UniGene: Hs.647067