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SMARCD2 Antibody

  • 货号：
    CSB-PA021809GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q92925
  • 基因名：
    SMARCD2
  • 别名：
    SMARCD2 antibody; BAF60B antibody; PRO2451 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 antibody; 60 kDa BRG-1/Brm-associated factor subunit B antibody; BRG1-associated factor 60B antibody; BAF60B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SMARCD2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation.
  • 基因功能参考文献：
    1. Data show that both CEBPE and SMARCD2 loss-of-function mutations identified in patients with neutrophil-specific granule deficiency (SGD) abolish the interaction with SWI/SNF and secondary granule gene expression, thus providing a molecular basis for this disease. PMID: 28369034
    2. Defective expression of SMARCD2 (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily D, member 2) leads to transcriptional and chromatin changes in acute myeloid leukemia (AML) promyelocytic cells, suggesting SMARCD2 is a key factor controlling myelopoiesis and is a potential tumor suppressor in leukemia. PMID: 28369036
    3. the Rac- and Unkempt-dependent process leading to BAF60b ubiquitination takes place in the nuclear compartment PMID: 20148946
  • 相关疾病：
    Specific granule deficiency 2 (SGD2)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    SMARCD family
  • 组织特异性：
    Isoform 2 is expressed in the pancreas.
  • 数据库链接：

    HGNC: 11107

    OMIM: 601736

    KEGG: hsa:6603

    STRING: 9606.ENSP00000392617

    UniGene: Hs.250581