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  4. SLC9A8 Antibody

SLC9A8 Antibody

  • 货号：
    CSB-PA008354
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Jurkat cells using NHE-8 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y2E8
  • 基因名：
    SLC9A8
  • 别名：
    Na(+)/H(+) exchanger 8 antibody; NHE 8 antibody; NHE-8 antibody; NHE8 antibody; SL9A8_HUMAN antibody; Slc9a8 antibody; Sodium/ hydrogen exchanger 8 antibody; Sodium/hydrogen exchanger 8 antibody; solute carrier family 9 (sodium/hydrogen exchanger); member 8 antibody; Solute carrier family 9 member 8 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human NHE-8.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IHC 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
  • 基因功能参考文献：
    1. work has uncovered a crucial role of NHE8 in acrosome biogenesis and suggests that some forms of human globozoospermia might be caused by a loss of function of this Na(+)/H(+) exchanger. PMID: 28476888
    2. NHE8 is expressed in goblet cells, and the inflammatory cytokine TNF-alpha downregulates NHE8 expression by a transcriptional mechanism. PMID: 26564720
    3. Exonic mutations in NHE8 cannot account for congenital sodium diarrhea. PMID: 21666503
    4. These data point to a role for the ion exchange activity of NHE8 being required to maintain endosome morphology. PMID: 20719963
    5. EGF inhibits intestinal NHE8 gene expression by reducing its basal transcription. PMID: 20375273
    6. NHE8 is expressed along the gastrointestinal tract and NHE8 is a functional Na(+)/H(+) exchanger with kinetic characteristics that differ from other apically expressed NHE isoforms. PMID: 18209477
    7. Tumor necrosis factor-alpha downregulates intestinal NHE8 expression by reducing basal promoter activity. PMID: 19109523

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  • 亚细胞定位：
    Golgi apparatus membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
  • 组织特异性：
    Ubiquitous. Strongly expressed in skeletal muscle and kidney.
  • 数据库链接：

    HGNC: 20728

    OMIM: 612730

    KEGG: hsa:23315

    STRING: 9606.ENSP00000354966

    UniGene: Hs.444202