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SLC7A1 Antibody

  • 货号：
    CSB-PA021709LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA021709LA01HU diluted at 1:500 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA021709LA01HU diluted at 1:500 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA021709LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC7A1 Polyclonal antibody
  • Uniprot No.：
    P30825
  • 基因名：
    SLC7A1
  • 别名：
    Amino acid transporter cationic 1 antibody; ATRC1 antibody; CAT-1 antibody; CaT1 antibody; CTR1_HUMAN antibody; Ecotropic retroviral leukemia receptor homolog antibody; Ecotropic retroviral receptor antibody; Ecotropic retrovirus receptor homolog antibody; ERR antibody; HCAT1 antibody; High affinity cationic amino acid transporter 1 antibody; High-affinity cationic amino acid transporter-1 antibody; REC1L antibody; Slc7a1 antibody; Solute carrier family 7 (cationic amino acid transporter, y+ system) member 1 antibody; Solute carrier family 7 member 1 antibody; System Y+ basic amino acid transporter antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human High affinity cationic amino acid transporter 1 protein (430-492AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SLC7A1 Antibody (CSB-PA021709LA01HU)，的标记方式是Non-conjugated。对于SLC7A1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA021709LB01HU SLC7A1 Antibody, HRP conjugated ELISA
    FITC CSB-PA021709LC01HU SLC7A1 Antibody, FITC conjugated
    Biotin CSB-PA021709LD01HU SLC7A1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues.
  • 基因功能参考文献：
    1. Estradiol increases arginine transport and CAT-1 activity through modulation of constitutive signaling transduction pathways involving ERK. Progesterone inhibits arginine transport and CAT-1 via both PKCalpha and ERK1/2 phosphorylation. PMID: 26062636
    2. The rs41318021 polymorphism in the SLC7A1 gene was not associated with essential hypertension in 50-year-old subjects. PMID: 23841815
    3. Overexpression of arginine transporter CAT-1 is associated with accumulation of L-arginine and cell growth in human colorectal cancer tissue. PMID: 24040099
    4. CAT1, CAT2, and CAT3 localized in adult brains but with uneven distribution. PMID: 22870827
    5. mRNA levels for high-affinity CAT-1, expressed as a percentage of the wild-type value, are increased by an average 12% and 32% in mdx and transgenic mdx:utr mice respectively. PMID: 23009292
    6. The data demonstrates that CAT1 significantly (but most likely not exclusively) contributes to the cellular uptake of asymmetric dimethylarginine. PMID: 22705145
    7. In hypoxic human pulmonary microvascular endothelial cells, overexpression of CAT-1 resulted in significantly greater L-arginine transport and NO production PMID: 21923750
    8. In acute congestive heart failure acute renal impairment function and the modulation of metabolism and extracellular transport by the DDAH-1/CAT-1 system determine high ADMA and SDMA levels after therapy for acute congestive heart failure. PMID: 21722652
    9. Insulin increased hCATs-L-arginine transport, maximal transport capacity, and hCAT-1 expression. Sp1 nuclear protein abundance and binding to DNA, and SLC7A1 promoter activity was increased by insulin. PMID: 21302286
    10. Data show that the CAT-1 isoform plays a role in arginine uptake. PMID: 21308737
    11. PKC activation also resulted in ubiquitination of CAT-1 PMID: 21212261
    12. analysis of the genomic organization PMID: 11665818
    13. Stable polarized expression of hCAT-1 in an epithelial cell line. PMID: 11891586
    14. Keratinocytes express cationic amino acid transporters 1 and 2. Cationic amino acid transporter mediated L-arginine essential for inducible nitric oxide synthase and arginase enzyme, which modulate proliferation and differentiation of epidermal cells. PMID: 12787129
    15. Insulin-mediated stimulation of the L-arginine/NO pathway is thus associated with increased hCAT-1 and hCAT-2B mRNA, and eNOS expression PMID: 15064952
    16. Glomerular arginine uptake is elevated through modulation of CAT-1 expression, thus, contributing to the pathogenesis of hyperfiltration. Increased nitric oxide formation may play a role in this process. PMID: 15086470
    17. protein kinase C(PKC) did not phosphorylate human cationic amino acid transporter hCAT-1 directly as evidenced by in vivo phosphorylation experiments and mutational analysis, indicating an indirect action of PKC on hCAT-1 PMID: 15491978
    18. The CAT-1 is thought to supply substrate to endothelial NOS by virtue of its co-localisation with this enzyme. PMID: 15631944
    19. The present study identifies a key functionally active polymorphism in the 3'UTR of SLC7A1 [which] may account for the apparent link between altered endothelial function, L-arginine, and nitric oxide metabolism and predisposition to essential hypertension PMID: 17325243
    20. Ornithine uptake in retinal pigment epithelium is depdendent on induction of SLC7A1 mRNA and spermine. PMID: 17494634
    21. distribution of human cationic amino acid transporters 1 (hCAT1) and 2 (hCAT2) in healthy skin and compared it to psoriatic skin lesions by means of immunohistochemistry PMID: 18172665
    22. CAT1 is directly involved in erythropoiesis through supplying arginine to the blood cells. PMID: 18574322
    23. Data provide novel insights into the mechanism by which ss52051869 influences SLC7A1 gene expression. PMID: 19067360

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Amino acid-polyamine-organocation (APC) superfamily, Cationic amino acid transporter (CAT) (TC 2.A.3.3) family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 11057

    OMIM: 104615

    KEGG: hsa:6541

    STRING: 9606.ENSP00000370128

    UniGene: Hs.14846