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SLC6A15 Antibody

  • 货号：
    CSB-PA030180
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9H2J7
  • 基因名：
    SLC6A15
  • 别名：
    hv7 3 antibody; MGC87066 antibody; NTT73 antibody; Orphan sodium and chloride dependent neurotransmitter transporter NTT73 antibody; Orphan transporter v7 3 antibody; S6A15_HUMAN antibody; SBAT1 antibody; SLC6A15 antibody; sodium- and chloride-dependent neurotransmitter transporter NTT73 antibody; Sodium-coupled branched-chain amino-acid transporter 1 antibody; Sodium-dependent neutral amino acid transporter B(0)AT2 antibody; Solute carrier family 6 (neutral amino acid transporter) member 15 antibody; Solute carrier family 6 member 15 antibody; Transporter v7-3 antibody; V7 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human SLC6A15.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent.
  • 基因功能参考文献：
    1. We observed an association between the SLC6A15 rs1545843 and resting-state brain function of the corpus callosum, cingulum and the frontal, parietal, and temporal lobes in MDD patients, which may be involved in the pathogenesis of Major Depressive Disorder. There was no interaction between rs1545843 genotypes and disease status. PMID: 28915082
    2. This study provides the first evidence that, at least among Han Chinese patients with PD, AA genotype at rs1545843 in the SLC6A15 gene. PMID: 28320136
    3. an association between the risk allele of the SLC6A15 gene rs1545843 and the White Matter Tracts integrity of the PHC in Major Depressive Disorder patients, which is known to play an important role in the neural circuit involved in emotion processing. PMID: 27723767
    4. The SLC6A15 gene plays a role in adrenocorticotropic hormone (ACTH) and cortisol secretion during cognitive impairments in unipolar depression. PMID: 22475622
    5. SNP rs1545843 associated with with local gray matter volume in median cingulate gyrus PMID: 23820837
    6. The data from human genetics(SLC6A15), expression studies, brain imaging, and animal models suggest a pathophysiological mechanism for MD that may be accessible to drug targeting. PMID: 21521612
    7. SBAT1-mediated transport of BCAA, particularly leucine, may be an important source of amino nitrogen for neurotransmitter synthesis in glutamatergic and GABAergic neurons. PMID: 16226721
    8. The substrate profile of the NTT4/XT1-dependent activity is similar to that of the closely related B(0)AT2/SBAT1 (SLC6A15), including a submillimolar apparent affinity for proline and leucine and a low millimolar apparent affinity for glutamine. PMID: 19147495

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A15 subfamily
  • 组织特异性：
    Almost exclusively expressed in the brain.
  • 数据库链接：

    HGNC: 13621

    OMIM: 607971

    KEGG: hsa:55117

    STRING: 9606.ENSP00000266682

    UniGene: Hs.44424