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SLC6A11 Antibody

  • 中文名称：
    SLC6A11兔多克隆抗体
  • 货号：
    CSB-PA050094
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P48066
  • 基因名：
    SLC6A11
  • 别名：
    GABT3 antibody; GAT-3 antibody; GAT3 antibody; S6A11_HUMAN antibody; Slc6a11 antibody; Sodium- and chloride-dependent GABA transporter 3 antibody; Solute carrier family 6 member 11 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human GABA T-3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
  • 基因功能参考文献：
    1. GAT-3 expression was selectively decreased in the central amygdala of alcohol-dependent people compared to those who died of unrelated causes. PMID: 29930131
    2. GABA-transporter 3 was reduced by about 62% in severe hippocampal sclerosis samples PMID: 26212582
    3. results suggest that GABA receptor signaling pathway was associated with the increased susceptibility to TD in Korean schizophrenic patients PMID: 23795861
    4. Binding assays employing membrane preparations obtained from a stably GAT3 expressing HEK293 cell line and DDPM-1007 as nonlabeled GAT3 marker were performed. In these experiments specific binding of DDPM-1007 at GAT3 could be unambiguously detected. PMID: 23225341
    5. The results suggest that GAT3 c.1572T may be one of the contributing factors with a modest effect on antiepileptic drug (AEDs) pharmacoresistance in the epileptic brain. PMID: 21776001
    6. homology models of hGAT-2 and hGAT-3 were built and searched for (i) substrate conformation, (ii) prediction of substrate (inhibitor) interaction, and (iii) distinguishable allosteric Zn2+ inhibition by combining docking and MD calculations. PMID: 19450549

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A11 subfamily
  • 组织特异性：
    Widespread distribution in the brain.
  • 数据库链接：

    HGNC: 11044

    OMIM: 607952

    KEGG: hsa:6538

    STRING: 9606.ENSP00000254488

    UniGene: Hs.655078