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SLC52A1 Antibody

  • 货号：
    CSB-PA878904LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA878904LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA878904LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA878904LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC52A1 Polyclonal antibody
  • Uniprot No.：
    Q9NWF4
  • 基因名：
    SLC52A1
  • 别名：
    FLJ10060 antibody; G protein coupled receptor 172B antibody; GPCR antibody; GPCR42 antibody; hRFT1 antibody; member 1 antibody; OTTHUMP00000125300 antibody; PAR2 antibody; PERV-A receptor 2 antibody; PERVA receptor 2 antibody; Porcine endogenous retrovirus A receptor 2 antibody; Protein GPR172B antibody; Putative G protein coupled receptor GPCR42 antibody; Riboflavin transporter 1 antibody; riboflavin transporter antibody; S52A1_HUMAN antibody; SLC52A1 antibody; Solute carrier family 52 antibody; Solute carrier family 52, riboflavin transporter, member 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Solute carrier family 52, riboflavin transporter, member 1 protein (212-279AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SLC52A1 Antibody (CSB-PA878904LA01HU)，的标记方式是Non-conjugated。对于SLC52A1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA878904LB01HU SLC52A1 Antibody, HRP conjugated ELISA
    FITC CSB-PA878904LC01HU SLC52A1 Antibody, FITC conjugated
    Biotin CSB-PA878904LD01HU SLC52A1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption.; (Microbial infection) May function as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).
  • 基因功能参考文献：
    1. We here report a case of transient MADD, caused by a heterozygous intronic variation, c.1134+11G>A, in the SLC52A1 gene encoding RFVT1. This variation creates a binding site for the splice inhibitory hnRNP A1 protein and causes exon 4 skipping. Riboflavin deficiency and maternal malnutrition during pregnancy might have been the determining factor in the outcome of this case. PMID: 29122468
    2. In HT-29 cells, the RFVT1 protein level was drastically lower. In tumor tissues of patients with CRC, RFVT1 content was reduced at both protein and mRNA levels compared to normal mucosa. PMID: 29715086
    3. results are the first to reveal the identity of the minimal SLC52A1 promoter and to establish an important role for Sp-1 in its activity PMID: 25284511
    4. data suggest that MMND is a distinct clinical subgroup of childhood onset MND patients where the known genetic defects are so far negative. PMID: 24139842
    5. summary of recent findings on the cloning, nomenclature, functional characterization and genetic diseases of RFVT1/SLC52A1, RFVT2/SLC52A2 and RFVT3/SLC52A3 [review] PMID: 23506902
    6. Intestinal riboflavin uptake process undergoes differentiation-dependent upregulation and suggest that this is mediated (at least in part) via transcriptional mechanisms of SLC52A1 and SLC52A3. PMID: 23413253
    7. We demonstrated that TFAP-2gamma is one of the transcription factors involved in the PAR-2 expression in human villous trophoblast cells. PMID: 22702469
    8. Identification/characterization riboflavin trasporter (RFT1) as a novel riboflavin transporter. PMID: 18632736

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  • 相关疾病：
    Riboflavin deficiency (RBFVD)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Riboflavin transporter family
  • 组织特异性：
    Widely expressed. Highly expressed in the testis, placenta and small intestine. Expressed at lower level in other tissues.
  • 数据库链接：

    HGNC: 30225

    OMIM: 607883

    KEGG: hsa:55065

    STRING: 9606.ENSP00000254853

    UniGene: Hs.632247