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SLC44A1 Antibody

  • 货号：
    CSB-PA008369
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q8WWI5
  • 基因名：
    SLC44A1
  • 别名：
    CD 92 antibody; CD92 antibody; CD92 antigen antibody; CD92 protein antibody; CDW 92 antibody; CDw92 antibody; CDW92 antigen antibody; Choline transporter like protein 1 antibody; Choline transporter-like protein 1 antibody; CHTL 1 antibody; CHTL1 antibody; CTL 1 antibody; CTL1 antibody; CTL1_HUMAN antibody; RP11 287A8.1 antibody; slc44a1 antibody; Solute carrier family 44 member 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CD92.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Choline transporter. Involved in membrane synthesis and myelin production.
  • 基因功能参考文献：
    1. SLC44A1 and KLF13 may be involved in tumorigenesis and the metastasis of colon cancer by miRNA regulation PMID: 29408621
    2. The differential expression pattern of CTL1 and CTL2 suggests that CTL1 is the key transporter involved in choline transport from maternal circulation and both transporters are likely involved in stromal and endothelial cell choline transport. PMID: 26601765
    3. This study showed that SLC44A1-PRKCA fusion seems to be a specific characteristic of Papillary glioneuronal tumors with a high diagnostic value. PMID: 26671581
    4. Reduced CTL1 expression is associated with postural orthostatic tachycardia syndrome. PMID: 25466896
    5. NCI-H69 cells express the choline transporter CTL1 which uses a directed H(+) gradient as a driving force, and its transport functions in co-operation with NHE1. PMID: 23948665
    6. REVIEW highlights discovery and characterization of SLC44A1, describes its expression patterns and subcellular localization and summarizes evidence for the role of this choline transporter in the central nervous system. PMID: 22483272
    7. CTL1 is expressed in both SH-SY5Y and LA-N-2 cells and is responsible for choline uptake that relies on a directed hydrogen ion gradient as a driving force. PMID: 21185344
    8. In conclusion, choline transport in A549 cells is increased by treatment with DEX, and the increase is mediated by induction of functional choline transporters CTL1 and CTL2. PMID: 20410607
    9. This study provides the first example of CHT1 expression in neurons which do not use acetylcholine as neurotransmitter. PMID: 15691711
    10. Data suggest that an impaired choline transporter-like protein-1 trafficking is the key contributing factor to reduced choline uptake, subsequent to the PMA-induced THP-1 differentiation to macrophages. PMID: 16319125
    11. characterization the 5'-flanking region of the human (h)CTL1 gene and some of the possible mechanisms of its regulation, including promoter activity, splicing, and expression PMID: 16609143
    12. SLC44A1 mRNA and protein expression were down-regulated during choline deficiency. PMID: 19357133
    13. The presence of CTL1 protein in rat and human CNS regions, where it is found in neuronal, glial and endothelial cells, suggests that malfunction of this transporter could have important implications in nervous system development and repair. PMID: 19519661

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein.
  • 蛋白家族：
    CTL (choline transporter-like) family
  • 组织特异性：
    Expressed in various cells of the hematopoietic system.
  • 数据库链接：

    HGNC: 18798

    OMIM: 606105

    KEGG: hsa:23446

    STRING: 9606.ENSP00000363852

    UniGene: Hs.573495